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Impaired hepatitis C virus-specific T cell responses and recurrent hepatitis C virus in HIV coinfection
(Public Library of Science, 2006)
Background: Hepatitis C virus (HCV)-specific T cell responses are critical for spontaneous resolution of HCV viremia. Here we examined the effect of a lymphotropic virus, HIV-1, on the ability of coinfected patients to ...
COPI Activity Coupled with Fatty Acid Biosynthesis is Required for Viral Replication
(Public Library of Science, 2006)
During infection by diverse viral families, RNA replication occurs on the surface of virally induced cytoplasmic membranes of cellular origin. How this process is regulated, and which cellular factors are required, has ...
Inducing Cross-Clade Neutralizing Antibodies against HIV-1 by Immunofocusing
(Public Library of Science, 2008)
Background: Although vaccines are important in preventing viral infections by inducing neutralizing antibodies (nAbs), HIV-1 has proven to be a difficult target and escapes humoral immunity through various mechanisms. We ...
Common Genetic Variation and the Control of HIV-1 in Humans
(Public Library of Science, 2009)
To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic ...
Microbial Translocation Is Associated with Increased Monocyte Activation and Dementia in AIDS Patients
(Public Library of Science, 2008)
Elevated plasma lipopolysaccharide (LPS), an indicator of microbial translocation from the gut, is a likely cause of systemic immune activation in chronic HIV infection. LPS induces monocyte activation and trafficking into ...