Browsing FAS Theses and Dissertations by Author "Cichowski, Karen"
Now showing items 1-3 of 3
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Co-targeting Translation Initiation and the RAS/ERK Pathway for the Treatment of KRAS-mutant Lung Cancer
Nardi, Francesca (2023-12-12)Lung cancer is the leading cause of cancer-related death worldwide with non-small cell lung cancer (NSCLC) being the most frequent subtype. Among the genetic alterations associated with NSCLC, activating mutations in the ... -
Epigenetic based therapeutic strategies to drive differentiation and death in KRAS mutant colorectal cancers
Loi, Patrick (2023-06-01)Colorectal cancer (CRC) is one of the leading causes cancer deaths worldwide, and advanced metastatic disease is still incurable. Mutations in the KRAS oncogene occur in 30-50% of all CRC and render the malignancy resistant ... -
Loss of Insulin Receptor Substrates 1 and 2 Suppresses Kras-Driven Non-Small Cell Lung Cancer
Xu, He (Clare) (2017-07-06)Lung cancer remains the leading cause of cancer death worldwide, with non-small cell lung cancer (NSCLC) being the majority of diagnosed cases of lung cancer. Mutant KRAS is found in about 25% of all NSCLC and has proved ...