Browsing FAS Theses and Dissertations by Author "Benoist, Christophe"

Now showing items 1-5 of 5

    • Circadian Regulation of Regulatory T Cells in Visceral Adipose Tissue 

      Xiao, Tianli (2021-09-07)
      Regulatory T cells (Tregs) in non-lymphoid tissues provide critical brakes on inflammation and control tissue homeostasis. While tissue Tregs are phenotypically diverse, they may adopt common mechanisms to optimize their ...

    • Decoding Regulatory T Cell Transcription Factor Networks: From Identity to Diversity 

      Chowdhary, Kaitavjeet (2023-11-21)
      Foxp3+CD4+ regulatory T cells (Tregs) are dominant controllers of immunological and organismal homeostasis. Tregs play diverse functional roles in lymphoid tissues, where they can adopt specialized phenotypes in response ...

    • Lymph Node Stromal Cell Responses to Perinatal T Cell Waves 

      Jayewickreme, Teshika (2023-11-21)
      The perinatal period is a critical time-window in establishing T-cell tolerance. Regulatory T cells (Tregs) made during the first two weeks of life are key drivers of perinatal tolerance induction, but how these cells are ...

    • Thymic Mechanisms of T Cell Tolerance 

      Michelson, Daniel Ahn (2023-06-01)
      Peripheral-tissue antigen (PTA) expression by medullary thymic epithelial cells (mTECs) eliminates self-reactive T cells from the immune repertoire, protecting against autoimmunity. The transcription factor (TF) Aire plays ...

    • Uncovering Stromal Cell Functions in Acute and Chronic Muscle Injuries 

      Yaghi, Omar Khaled (2022-08-16)
      Skeletal muscle injuries are highly prevalent, yet current therapies are poor and often limited to symptom management. Inadequate muscle repair can lead to impaired mobility, not only affecting patients’ quality of life ...