Browsing FAS Theses and Dissertations by Title
Now showing items 2896-2915 of 6566
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I Go, You Go: Searching for Strength and Self in the American Gym
(2016-05-12)This ethnography is based on 48 months of detailed participation, interviews, and observation with active gymgoers at three middle-class gyms in Chicago. It is a study of a particular social institution that, despite its ... -
I Spit Upon the Noble: The Epicurean Critique of Love of Honor and the Origins of Modernity
(2013-10-18)Modern liberal democracies regard "pursuit of happiness" as one of the fundamental rights that governments are instituted to protect - but modern political thought has comparatively little to say about happiness itself. ... -
I Want to Go to the Future Please: Jenny Holzer and the End of a Century
(2013-03-18)The task of this dissertation is to assess the historical conditions that permitted Jenny Holzer to formulate a practice premised on language and conceptions of public space to break from historical avant-garde and ... -
“I Whisper Into the Radio Ear”: Radio Sound and Russian Modernist Poetics
(2016-09-12)In 1924, the Soviet “electrification” was followed by “radiofication,” a gradual introduction of broadcast radio that led to novel forms of newscasts, political propaganda, and creative formats. This dissertation is the ... -
"I Worship Black Gods": Formation of an African American Lucumi Religious Subjectivity
(2015-05-17)In 1959, Christopher Oliana and Walter “Serge” King took a historic journey to pre-revolutionary Cuba that would change the religious trajectory of numerous African Americans, particularly in New York City. They became the ... -
I. Chiral Squaramide Catalysts for Lewis Acid Activation in Asymmetric Catalysis II. Catalytic, Stereoselective Difluorination Reactions
(2016-12-13)In Chapter 1, we report the observation that chiral squaramide hydrogen-bond (H-bond) donor catalysts act cooperatively with trialkylsilyl trifluoromethanesulfonates (silyl triflates) to promote enantioselective (4+3) ... -
I. Completion of a Total Synthesis of Peloruside A. II. Studies toward the Total Synthesis of Spiro-Prorocentrimine
(2013-03-05)I. Completion of a Total Synthesis of Peloruside A: The completion of a 22 step synthesis of the marine natural product peloruside A is presented. The second generation strategy cuts 10 steps from longest linear sequence ... -
I. Enantioselective Acylation of Silyl Ketene Acetals through Fluoride Anion-Binding Catalysis II. Development of a Practical Method for the Synthesis of Highly Enantioenriched Trans-1,2-Amino Alcohols
(2013-08-21)A highly enantioselective acylation of silyl ketene acetals with acyl fluorides was developed to generate useful α,α-disubstituted butyrolactone products in high yield and excellent enantioselectivities. This transformation ... -
I. Engaging Cationic Intermediates in Asymmetric Catalysis: Enantioselective Reactions of Carbenium Ions and N,N-Dialkyliminium Ions II. Enantioselective Catalysis of the Cope-Type Hydroamination by H-Bond Donors
(2013-09-16)The research described here explores the ability of dual H-bond donor catalysts to induce asymmetry in a variety of synthetically useful transformations that proceed via diverse reactive intermediates. In Chapters 1-3, ... -
I. Stereoselective Construction of Polycyclic Architectures: Enantioselective Catalytic Transannular Ketone-Ene Reactions and an Enantioselective Total Synthesis of (+)-Reserpine II. Synthesis of Chiral Bisthioureas for Anion-Abstraction Catalysis
(2013-10-18)The research presented herein explores three aspects of asymmetric catalysis: (1) the development of new catalytic enantioselective reactions, (2) the application of stereoselective catalysis to natural product total ... -
I. Synthesis of C4-Modified Tetracyclines II. Aldolizations of Pseudoephenamine Glycinamide and Applications Toward the Synthesis of Monocyclic β-Lactam Antibiotics
(2015-05-14)Part one of this thesis describes the production of C4-modified tetracycline derivatives. Our synthetic strategy originally targeted SF2575, a C4-oxygenated tetracycline analog with antiproliferative properties, but was ... -
I. Targeted β-catenin Ubiquitination and Degradation Using Bifunctional Stapled Peptides II. Studies on Cell Penetration by Stapled Peptides
(2014-02-25)Hydrocarbon-stapled alpha-helical peptides represent a relatively new class of synthetic peptidomimetics capable of inhibiting protein-protein interactions. It has been shown that hydrocarbon "staples" spanning one or two ... -
IAP Inhibitors as Novel Immune Adjuvants for Scaffold Based Cancer Vaccines
(2015-05-14)Inhibitors of apoptosis (IAP) antagonists are nearing approval as promising new candidates for cancer therapy, particularly for solid tumors. Previous work had uncovered the ability of the monomer version of this drug to ... -
Ice Stream Variability and Links to Climate
(2015-09-22)This dissertation explores the variability and climatic importance of ice streams, regions of fast flow in ice sheets. Observations indicate that ice stream variability plays an important role in the current mass balance ... -
Ideas in Practice: the Political Economy of Chinese State Intervention During the New Policies Period (1068-1085)
(2015-01-13)I take the New Policies period (1068-1085) to be a critical juncture in Chinese history during which, for the first time, the Chinese state initiated systematic intervention into the market. This period witnessed the failure ... -
Identification and Analysis of a New Tumor and Metastasis Suppressor Gene, RASAL2
(2013-10-08)RAS is one of the most commonly mutated genes in human cancer; its aberrant activation drives tumor cell proliferation and survival. However, RAS mutations are rare in some cancers, including breast cancer, even though ... -
Identification and Characterization of Genes Essential for Human Brain Development
(2012-10-18)The human brain is a network of ninety billion neurons that allows for many of the behavioral adaptations considered unique to our species. One-fifth of these neurons are layered in an epithelial sheet known as the cerebral ... -
Identification and Characterization of Genetic Variants Conveying Risk to Develop Uterine Leiomyomata
(2013-01-02)Uterine leiomyomata (UL), commonly known as fibroids, are a major public health problem given their extreme prevalence (>70%), severity of associated symptoms, and indication for hysterectomies in women of reproductive ... -
Identification and Characterization of Intermediates during Folding on the β-Barrel Assembly Machine in Escherichia coli
(2014-06-06)β-barrel membrane proteins play important structural and functional roles in Gram negative bacteria and in mitochondria and chloroplasts of eukaryotes. A conserved machine is responsible for the folding and insertion of ... -
Identification and Characterization of Novel Cancer Genetic Dependencies
(2023-06-01)Cancer cells have unique genetic dependencies that can be exploited therapeutically, leading to successful targeted therapeutic drugs that benefit patients. However, many cancers remain undruggable, and many drug development ...