Browsing FAS Theses and Dissertations by Title
Now showing items 4192-4211 of 6566
-
O-GlcNAc modification of casein kinase 2 alpha alters the phosphoproteome
(2022-05-12)Post-translational modifications govern protein function and are paramount to many signaling networks in cells. How different post-translational modifications intersect to result in complex signaling outcomes represents a ... -
Obeying Those in Authority: the Hidden Political Message in Twelver Exegesis
(2014-06-06)In the tenth century, a confluence of two unrelated events shaped the Twelver Shia community in Baghdad: the Occultation of the Twelfth Imam in 939/329 and the takeover of Baghdad in 945 by the Buyid princes, who were ... -
ObjectiveGAN: Using Generative Adversarial Networks and Reinforcement Learning to Fine-Tune Sequence Generation Models
(2017-07-14)When generating sequences with recurrent neural networks, naive reinforcement learning can be used to give ``hints" and guide the model's generative process towards an arbitrary objective criterion on the output data. For ... -
Objectivity and Intersubjectivity in Moral Philosophy
(2017-05-05)Many people believe that morality is objective. My dissertation explores whether we have good grounds for this belief, and whether we should find it troubling if we do not. I defend negative answers to both questions. The ... -
Observation of the Higgs boson in the WW* channel and search for Higgs boson pair production in the bb̄bb̄ channel with the ATLAS detector
(2016-05-12)This dissertation presents the observation and measurement of the Higgs boson in the H→ WW*→ ℓνℓν channel at √s = 7 TeV and √s = 8 TeV and a search for Higgs pair production in the HH→ bb̄bb̄ channel at √s = 13 TeV with ... -
Observational Constraints on Dissipative Dark Matter
(2017-05-15)Models for dissipative, disk-forming dark matter are explored in the context of Double Disk Dark Matter. The basics of the model are reviewed. Observational constraints are placed on the parameter space of these models. ... -
Observational Electromagnetic Signatures of Spinning Black Holes
(2021-05-13)As we enter the era of precision black hole imaging, identifying universal observational signa- tures which of the near horizon strong field region will become increasingly useful in constraining the parameters–mass, spin, ... -
Observing atmospheric formaldehyde from space: validation and implications
(2017-01-06)Formaldehyde (HCHO) column data from satellites are widely used as a proxy for emissions of volatile organic compounds (VOCs), but validation of the data has been extremely limited. Here I use highly accurate HCHO aircraft ... -
Observing Seismic Variations by Earth and Lab Fluids and Fractures
(2024-05-06)Understanding the mechanical dynamics within the Earth's crust is crucial for both environmental and energy sustainability. These dynamics are often tied to mechanical deformations triggered by variations in fluid pressure ... -
The Ocean of Inquiry: A Neglected Classic of Late Advaita Vedānta
(2013-08-12)The Ocean of Inquiry is a vernacular compendium of Advaita Vedānta, one of the most influential traditions of South Asian religion and philosophy, especially in modern times. Its author, Niścaldās (ca. 1791 – 1863), was a ... -
Of Unsound Mind: Madness and Mental Health in Asian American Literature
(2023-09-07)This project interrogates four conditions characterized as being “of unsound mind:” hysteria, mutism, psychosis, and depression in 20th century and contemporary Asian American literature. Through reading texts by Hisaye ... -
Of Xist and Dosage Compensation in Mammalian Development and Disease
(2017-01-10)In mammals, equalized gene dosage between the sexes is ensured by a process called X chromosome inactivation (XCI). XCI, mediated by the long noncoding RNA Xist, initiates early in female embryogenesis, both in extraembryonic ... -
Off Policy Reinforcement Learning for Real-World Settings
(2021-07-12)In this dissertation, we aim to adapt reinforcement learning (RL) to real-world, high-risk settings. We study how to optimize sequential decision-making in complex settings with large observational data repositories where ... -
Off-Policy Evaluation of Reinforcement Learning in Healthcare
(2020-08-10)Reinforcement learning is a method for learning optimal strategies for tasks which require making sequences of decisions. The ability to make decisions in a manner which balances short versus long term outcomes makes ... -
"Oft Have I Heard of Sanctuary Men": Fictions of Refuge in Early Shakespeare
(2014-06-06)This study weaves together several strands of inquiry. On the level of dramatic analysis, I look to understand how "sanctuary" spaces operate in Shakespeare's early plays and the ways in which such zones relate to genre. ... -
Oil and Water: Essays on the Economics of Natural Resource Usage
(2016-05-24)As the developing world continues its pace of rapid growth and the threat of climate change intensifies, the economics of natural resource usage become increasingly important. From the perspective of both economic efficiency ... -
The Old Khotanese Metanalysis
(2016-05-17)A range of present stems in Khotanese which historically ended in a consonant behave synchronically as vowel final stems. Forms like bvāre ‘they know’ or bvāne ‘may I know’ imply a synchronic stem bu-, but most scholars ... -
Olfactory Evidence Accumulation in Mice
(2021-07-12)In nature, odor cues from distant objects are sparse and highly fluctuating due to turbulent airflow. Animals may integrate odor concentration sampled over time rather than rely on transient odor concentration to effectively ... -
Olfactory Transduction and Taste Processing in Drosophila
(2013-01-02)We completed two separate studies examining chemosensation in Drosophila. The first study investigated taste processing. It was our aim in this study to identify and characterize higher-order gustatory neurons. Our strategy ... -
Oligopaints: Highly Programmable Oligonucleotide Probes for Visualizing Genomes in Situ
(2015-01-29)Fluorescence in situ hybridization (FISH) is a powerful assay that can visualize the position of DNA and RNA molecules in individual cells. Here, I describe the development of a method that utilizes complex oligonucleotide ...