Browsing FAS Theses and Dissertations by Keyword "3D genome"
Now showing items 1-2 of 2
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Illuminating chromatin organization at nuclear landmarks using chemical genomics
(2023-09-06)The three-dimensional conformation of chromatin is key to regulating gene expression and maintaining cell states. Protein cofactors are essential for the formation and maintenance of this DNA structure, but the ways in ... -
The impact of toggling 3D genome structure on Polycomb-mediated repression, interchromosomal interactions, and X-inactivation
(2021-11-16)Microscopy and chromosome conformation capture (3C) techniques revealed that mammalian genomes fold into chromosome territories, compartmental structures such as active/inactive (A/B) compartments, and dynamic chromatin ...