Browsing FAS Theses and Dissertations by Keyword "Drug discovery"
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Accelerating drug discovery with quantum chemistry, machine learning, and molecular dynamics
(2023-11-21)Drug discovery is a long and expensive process. Bringing a new drug to market takes an average of 12 years and costs $2.9 billion (USD, 2013). Most new candidates fail during pre-clinical development, and 90% of the remaining ... -
Chemoproteomic target-class drug discovery against the deubiquitinating enzymes
(2022-03-17)Modern small molecule drug discovery is dominated, and subsequently limited by a paradigm of reversible non-covalent inhibitors. The deubiquitinating enzymes (DUBs) is a class of ~100 proteases that regulate normal and ... -
From Probes to Therapeutics: Chemical Biology Studies of Anaplastic Lymphoma Kinase (ALK) and Cereblon
(2020-01-22)Although there is still discussion surrounding the exact definition of the field, chemical biology is generally described as the development and deployment of a chemical toolbox to manipulate biological systems. The two ...