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Transcriptional Regulation of Synapse Remodeling in C. elegans
(2012-12-19)
The ability of a neuron to alter its synaptic connections during development is essential to circuit assembly. Synapse remodeling or refinement has been observed in many species and many neuronal circuits, yet the mechanisms ...
Mechanistic Studies of Polycomb Group Proteins
(2012-12-20)
Most cells within multicellular organisms contain the same genetic information, yet the appropriate tissue-specific expression of genes is required for the proper formation of adult tissues. Genes can either be “turned on” ...
Elucidating the Regulation and Effectors of the Breast Cancer Oncogene, IKKepsilon
(2012-12-19)
The IkappaB kinase epsilon (IKKepsilon, IKKi, IKBKE) is both a regulator of innate immunity and a breast cancer oncogene that is amplified and overexpressed in ~30% of breast cancers. IKKepsilon promotes malignant ...
Structural Studies on the eIF4A-eIF4G Interaction in Translation Initiation
(2012-12-20)
Protein synthesis is an important cellular process, and the RNA helicase eIF4A plays a vital role in unwinding messenger RNA and scanning during translation initiation. eIF4A has little activity in isolation, but is modulated ...
Chromatin-Modifying Factors in Zebrafish Models of Rhabdomyosarcoma and Hematopoiesis
(2012-12-20)
Epigenetics, or the reversible and heritable marks of gene regulation not including DNA sequence, encompasses modifications on both the DNA and histones and is as important as the DNA sequence itself. Gene transcription, ...
Trapped Antihydrogen in Its Ground State
(2012-12-17)
Antihydrogen atoms \((\bar{H})\) are confined in a magnetic quadrupole trap for 15 to 1000 s - long enough to ensure that they reach their ground state. This milestone brings us closer to the long-term goal of precise ...
Essays in Entrepreneurial Finance
(2012-12-19)
In the first essay, I show that the transition to public equity markets have important implications to firms’ innovative process. To establish a causal effect of the IPO, I compare the long-run innovation of firms that ...
Topological Properties of Interacting Fermionic Systems
(2012-12-17)
This thesis is a study of three categories of problems in fermionic systems for which topology plays an important role: (i) The properties of zero modes arising in systems of fermions interacting with a bosonic background, ...
The Fourth Branch of Government: The Role of Interest Groups, the Media, and Political Advertisements in Contemporary Health Policy Debates
(2012-12-13)
The first part of this dissertation explores whether interest group-sponsored political advertising campaigns influence how journalists frame health policy debates. The paper employs propensity score matching techniques, ...
Mechanical Intelligence in Millimeter-Scale Machines
(2012-12-19)
Advances in millimeter-scale fabrication processes have enabled rapid progress towards the development of flapping wing micro air vehicles with wing spans of several centimeters and a system mass on the order of 100mg. ...