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Regulation of the Inflamed Tumor Phenotype in Melanoma Immunotherapy
(2016-05-02)
Immune checkpoint inhibitors targeting cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1) pathways can deliver durable anti-tumor effects. However, a major fraction of metastatic cancer ...
Homology and Heterology Effects in Drosophila: Cohesin and Condensin as Chromosome Choreographers
(2016-05-02)
The organization of interphase nuclei has numerous consequences for gene expression and genome stability in eukaryotes. Here, we present studies of chromosome organization in Drosophila melanogaster over the course of the ...
Nucleotide Modifications of RNA Suppress RIG-I Antiviral Signaling by Unique Mechanisms
(2016-05-02)
In order to counter pathogen infection while preventing autoimmune responses, the human innate immune system must be precisely regulated to distinguish “self” from “non-self”. Pattern recognition receptors detect “non-self” ...
Exploring Intra-tumor Cooperation in Metastasis and Drug Resistance using Heterogeneous Xenograft Models of Breast Cancer
(2016-05-03)
Breast cancer is a highly heterogeneous disease, having not only several intrinsic sub-types but also significant sub-clonal heterogeneity within tumors. Intra-tumor heterogeneity can have profound impact on tumor evolution, ...
Mechanisms of Resistance to MAPK Pathway Inhibition in RAS-Mutant Cancers
(2016-05-03)
The RAS family of genes are among the most frequently mutated genes in human cancers, including nearly all pancreatic cancers, ~40% of colorectal cancers, and ~30% of lung cancers. Although most RAS-mutant cancers depend ...
Characterization and Disruption of Cis Regulatory Elements in Cancer
(2016-05-11)
Enhancers are cis regulatory elements that play key roles in the control of cell-type specific gene expression programs. In cancer, enhancer deregulation plays a key role in maintaining gene regulatory programs that underlie ...
Identification of Small Molecule Inhibitors of 3-Phosphoglycerate Dehydrogenase to Target Serine Biosynthesis in Cancers
(2016-01-21)
Cancer cells are known to reprogram their metabolism in order to promote growth and proliferation. The amino acid serine is utilized in a plethora of anabolic reactions and supports the synthesis of all three major ...
Investigating the Phosphoinositide 3-Kinase (PI3K) Pathway for Therapeutic Strategies for Breast Cancer
(2016-01-05)
Despite major advances in our understanding of the etiology of breast cancer, it remains a leading cause of cancer death in women worldwide. This warrants the search for novel alternatives for diagnosis and therapeutic ...
Phosphatases and microRNAs: Investigations in the Context of DNA Damage
(2016-01-22)
Integrity of the cellular genome is constantly threatened by various sources of DNA damage that cause a variety of lesions including double strand breaks. Cells respond to such insults by upregulating the DNA damage response, ...
Lin28a/b in the Regulation of Developmental Timing and Tumorigenesis
(2016-05-10)
The heterochronic genes Lin28a/b and let-7 have long been known to play critical roles in the development of organisms from worms to humans. These highly conserved genes have emerged as factors that regulate self-renewal, ...