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Formation of a Termination-Resistant RNA Polymerase Complex: Studies on the Phage 82 Q Protein
(2015-07-22)
Due to their early discovery, relative simplicity, and well-defined function, the Q antiterminator proteins of bacteriophage lambda and related lambdoid phages serve as a model for understanding how the elongation and ...
Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis
(2016-05-14)
Despite its eponymous association with proteotoxic stress, heat shock factor 1 (Hsf1 in yeast and HSF1 in mammals) is required for viability of yeast and many human cancer cells, yet its essential role remains undefined. ...
Plasmodium's Crossroads: Deciphering the Molecular Pathway That Leads to Malaria Transmission
(2015-05-13)
Plasmodium falciparum is the causative agent of the most severe form of malaria. Transmission from humans to mosquito vectors is an essential step in this eukaryotic parasite‘s life cycle and in the spread of malaria ...
Microbiome-Targeted Interventions for Colitis-Associated Bacteria
(2016-05-06)
Complex interactions between mammalian hosts and their gut microbes have evolved over many millennia and have established a sophisticated communication system that is essential for symbiosis and mutualism. Perturbations ...
Post-Transcriptional Control of Multicellularity in Bacillus subtilis
(2016-05-13)
Bacteria are capable of sensing changes in their environment and responding to those changes by altering patterns of gene expression. There are many mechanisms by which bacteria can sense internal and external signals. The ...
Mechanisms Controlling the Cell Envelope Remodeling Activities of the Escherichia Coli Cytokinetic Ring
(2016-05-13)
In Escherichia coli, cytokinesis requires the constriction of all the cell envelope layers: the inner membrane, the peptidoglycan (PG) cell wall and the outer membrane (OM). Such dramatic cell envelope remodeling requires ...
Synthetic organization in vitro and in vivo
(2016-05-14)
Organized complexity is a hallmark of biology in general, and eukaryotes in particular. This phenomenon abounds across many size scales ranging from tissues to organelles to protein complexes. Scaffold molecules, which ...
Advances in Phage-Assisted Continuous Evolution and Application to Overcoming Bioinsecticide Resistance
(2016-05-20)
The Bacillus thuringiensis δ-endotoxins (Bt toxins) are widely used insecticidal proteins in engineered crops that provide agricultural, economic, and environmental benefits, constituting a substantial and increasingly ...
Investigation of the Mechanism That Powers DNA Translocation During Bacterial Natural Transformation
(2016-07-26)
If deoxyribonucleic acids are the building blocks of life, perhaps the proteins that move, shape, and assemble nucleic acids should be called architects. These proteins come in every size and shape and have vastly different ...
A novel sigma factor antagonist that binds to RNA polymerase
(2015-05-18)
Sigma (σ) factors direct programs of gene expression by binding to and determining the promoter recognition specificity of RNA polymerase (RNAP). Genes transcribed under the control of alternative σs allow cells to respond ...