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Contextual Modulation of Early Visual Processing and the Role of Cortico-Cortical Feedback
(2016-05-14)
How does the brain form a useful representation of its external environment from the astoundingly complex patterns of sensory signals it receives? This question has motivated the field of systems neuroscience for decades. ...
Postnatal Genome Editing With CRISPR
(2016-05-18)
Targeted genome editing holds tremendous promise for permanent correction of many genetic diseases. The recently developed CRISPR/Cas9 genome-editing tool exhibits facile programmability and robust gene-editing efficiency, ...
Emergence of Reward Coding in the Olfactory System
(2016-05-17)
Identifying dangerous or rewarding elements in an animal’s surroundings is an important – if not primary – function of sensory systems. This holds particularly true for the mouse olfactory system since odors convey crucial ...
Combinatorial Pathway Modulation Toward Ex Vivo Maintenance and Propagation of Hematopoietic Stem Cells
(2016-05-18)
Hematopoietic stem cells (HSCs) sustain continuous turnover and maintenance of all blood lineages through organismal lifespan. The extensive regenerative potential of HSCs has been harnessed in transplantation medicine ...
Investigating Mechanisms of DNA Double Strand Break Joining of Switch Regions During IgH Class Switch Recombination
(2016-05-19)
During B cell development, RAG endonuclease cleaves immunoglobulin heavy chain (IgH) V, D, and J gene segments and orchestrates their fusion as deletional events that assemble a V(D)J exon in the same transcriptional ...
The Brain Has an Innate Immune Response That Can Limit Virus Spread
(2016-05-17)
The brain has a tightly regulated environment that protects non-regenerating post-mitotic neurons and limits inflammation, which led to its description as a site of ‘immune privilege’. For example, viral and bacterial ...
Neural Circuit Mechanisms Underlying Skill Learning, Adaptation, and Maintenance
(2016-05-18)
Part I
Mastering a motor skill, such as a playing the guitar, requires precisely controlling both spatial and temporal aspects of motor output – that is, what movements to perform when. While it is generally assumed that ...
Resistance to Targeted Therapy in Sonic Hedgehog Subgroup Medulloblastoma: Mechanisms and Treatment Strategies
(2016-05-17)
Aberrant activation of the Sonic Hedgehog (Shh) signaling network is implicated in many human cancers, including the most common cancer, basal cell carcinoma (BCC) and the brain tumor medulloblastoma. Suppressing Shh ...
Cell Shape and Treatment Duration: How They Influence a Cancer Cell's Response to TNF
(2016-05-17)
The purpose of my research was to investigate the sources of heterogeneity in cellular decisions that are based on both external and internal cues. I used the signaling network induced by tumor necrosis factor (TNF) as a ...
Coding of Internal Senses: Vagal Gut-to-Brain Circuits
(2016-05-17)
Our ability to detect features of environments in and around us is fundamental. Organisms have developed highly specialized systems to allow for transduction of a broad variety of stimuli to convey sensory information to ...