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Loss of Insulin Receptor Substrates 1 and 2 Suppresses Kras-Driven Non-Small Cell Lung Cancer
(2017-07-06)
Lung cancer remains the leading cause of cancer death worldwide, with non-small cell lung cancer (NSCLC) being the majority of diagnosed cases of lung cancer. Mutant KRAS is found in about 25% of all NSCLC and has proved ...
Type 2 Diabetes-Associated Variants Disrupt Function of SLC16A11
(2017-04-20)
Type 2 Diabetes (T2D) affects individuals of Mexican and Latin American descent at twice the rate seen in populations of European descent. Recently a risk haplotype in SLC16A11 that explains ~20% of the increased T2D ...
Investigation of the Gene Expression Dynamics of Early Mammalian Germ Layer Differentiation
(2017-11-02)
The mechanisms regulating the timing of developmental processes are poorly understood. To systematically investigate the timing of development and its underlying mechanisms, the dynamics of development must first be ...
Clp-Mediated Regulation of the Mycobacterial Cell Cycle
(2017-04-12)
Tuberculosis is currently the most deadly infectious disease worldwide. Given the high rates of treatment failure, new antibiotics are desperately needed. Antibacterial drugs typically target DNA replication, cell growth, ...
Repression of the protein kinase PIM3 by an mTORC1-regulated microRNA
(2017-09-08)
The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of cell growth that is often aberrantly activated in cancer. However, mTORC1 inhibitors, such as rapamycin, have limited effectiveness as single ...
The processes mediating capsid trafficking during human cytomegalovirus nuclear egress
(2017-05-11)
Herpesviruses are widespread pathogens that cause or contribute to an array of human diseases. Viral DNA synthesis, capsid assembly, and packaging occur in nucleoplasmic structures called replication compartments (RCs), ...
Investigating the Role of ARID1A Inactivation in Colon Cancer Pathogenesis
(2017-05-12)
The genomics-era search for cancer-causing mutations has revealed epigenomic regulators, in particular SWI/SNF chromatin remodeling complexes, as major targets of mutation. Genes encoding SWI/SNF subunits are collectively ...
The Role of MreB in Producing Rod-Shaped Bacterial Cells
(2017-09-08)
MreB, an actin homolog, is known to form short, membrane-associated filaments that move circumferentially in rod-shaped bacteria, in association with cell wall-synthesizing enzymes. Despite being essential for rod shape, ...
Regulation of RIPK1 Dependent Apoptosis and Necroptosis
(2017-01-03)
RIPK1 is a Ser/Thr kinase critically involved in mediating multiple signaling pathways activated by TNFa. When cells are stimulated by TNFa, RIPK1 is rapidly recruited to the intracellular domain of TNFR1 to form the TNF-RSC ...
Shining Light on Microtubule Nucleation: FRET Measurements With Bayesian Analysis of FLIM
(2017-05-09)
The mitotic spindle is a self-organizing structure that segregates chromosomes during cell division. The spindle is composed of microtubules and accessory proteins, and microtubules are composed of the protein tubulin. ...