Search
Now showing items 1-10 of 25
Combinatorial Pathway Modulation Toward Ex Vivo Maintenance and Propagation of Hematopoietic Stem Cells
(2016-05-18)
Hematopoietic stem cells (HSCs) sustain continuous turnover and maintenance of all blood lineages through organismal lifespan. The extensive regenerative potential of HSCs has been harnessed in transplantation medicine ...
Resistance to Targeted Therapy in Sonic Hedgehog Subgroup Medulloblastoma: Mechanisms and Treatment Strategies
(2016-05-17)
Aberrant activation of the Sonic Hedgehog (Shh) signaling network is implicated in many human cancers, including the most common cancer, basal cell carcinoma (BCC) and the brain tumor medulloblastoma. Suppressing Shh ...
Cell Shape and Treatment Duration: How They Influence a Cancer Cell's Response to TNF
(2016-05-17)
The purpose of my research was to investigate the sources of heterogeneity in cellular decisions that are based on both external and internal cues. I used the signaling network induced by tumor necrosis factor (TNF) as a ...
Neurotoxic Mechanisms of the Chemotherapeutic Paclitaxel
(2016-05-04)
Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting side effect of multiple chemotherapeutic agents for which there are currently no prevention strategies. The widely used chemotherapeutic paclitaxel ...
Isogenic Human Pluripotent Stem Cell Models of Cardiovascular Disease-Associated Genetic Variation
(2016-03-30)
A complex interplay of genetic and environmental factors underlies the development of common human diseases such as cardiovascular disease. Despite widespread use of existing medications, coronary heart disease (CHD), ...
Regulation of Mitochondrial Distribution and Inheritance During Cell Division
(2016-05-13)
Mitochondria are crucial to the cell and perform numerous functions including generating cellular ATP, buffering calcium, and creating macromolecules. Mitochondria contain their own DNA and as such, cannot be synthesized ...
Organization of Postsynaptic Assembly by Filamin at the Drosophila Neuromuscular Junction
(2016-05-16)
Proper postsynaptic assembly is a fundamental requirement for circuit function, yet our understanding of its molecular mechanism is incomplete. The Drosophila neuromuscular junction is a powerful system for genetically ...
Spatial Control of Protein Homeostasis by Microtubule-Based Motors in Filamentous Fungi
(2016-04-22)
Extreme cell polarity places unique demands on long-range transport mediated by the microtubule-based motors dynein and kinesin. Accordingly, deficient protein homeostasis in highly polarized neurons, a process to which ...
A Novel Program of Ubiquitination Remodels the Erythroid Proteome During Terminal Differentiation
(2016-05-17)
The ubiquitin-proteasome system was initially discovered in reticulocytes, which undergo massive and rapid proteome remodeling. During terminal differentiation, hundreds of generic constituents of the cell undergo programmed ...
The Role of Proinflammatory Cytokines on Pancreatic Cell Plasticity
(2016-05-05)
Diabetes mellitus is a complex and heterogeneous group of metabolic diseases characterized by a disruption in blood glucose homeostasis. This could result from an autoimmune destruction of insulin-producing pancreatic beta ...