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Development and Deployment of Optical Instruments to Measure Trace Atmospheric Species: I. Water Isotopologues; II. Glyoxal; III. Iodine Monoxide
(2012-12-13)
Understanding future climate requires observations of trace species that can significantly influence the chemical or radiative properties of the atmosphere. The development of optical instruments, utilizing laser-systems ...
Progress toward the Total Synthesis of Lomaiviticins
(2012-12-20)
A synthetic plan for the dimeric diazobenzofluorene natural product lomaiviticin A and lomaiviticin B is presented. The route features a late-stage oxidative enolate dimerization of a monomeric oxanorbornanone, as well as ...
Metabolomics Strategies for Discovery of Biologically Active or Novel Metabolites
(2013-02-08)
Along with genes and proteins, metabolites play important roles in sustaining life. There remains much to be learned about the in vivo roles of metabolites. Metabolomics is a comparative tool to study global metabolite ...
Using Live Cell Imaging to Probe Biogenesis of the Gram-Negative Cell Envelope
(2013-02-08)
In Gram-negative bacteria, the three-layered cell envelope, including the cell wall, outer and inner membranes, is essential for cell survival in the changing, and often hostile environments. Conserved in all prokaryotes, ...
Studies on Application of Silyl Groups in Ring-Closing Metathesis Reactions and Fragment-Based Probe Discovery
(2012-12-19)
In efforts to search for tool compounds that are capable of probing normal and disease-associated biological processes, both quality and identity of the screening collection are very important. Towards this goal, ...
Small-Molecule Suppressors of Cytokine-Induced Beta-Cell Apoptosis
(2013-01-02)
Type-1 diabetes is caused by the autoimmune destruction of insulin-producing beta cells in the pancreas. Beta-cell apoptosis involves a complex set of signaling cascades initiated by \(interleukin-1\beta (IL-1\beta)\), ...
Reactions of Diketones and N-Allenoyloxazolidinones Catalyzed by Metal-Bis(oxazoline) Complexes
(2013-02-25)
This dissertation describes the investigation of the utility of metal–bis(oxazoline) complexes in catalytic asymmetric reactions. The development of Cu(II)-catalyzed regio- and enantioselective additions of silylketenthioacetals ...
Electronic Structure Predictions for Properties of Organic Materials
(2013-02-22)
Electronic structure calculations of organic molecules are an important set of tools to gain understanding of molecular structures. This thesis presents two separate contributions to applying quantum chemistry to organic ...
Nanowire Architectures for Next-Generation Solar Cells and Photonic Devices
(2013-02-15)
This thesis presents the design and synthesis of nanowires (NW) with targeted and tunable optical properties. Moreover, we show how single and assembled NW devices can enable new photovoltaic (PV) and photonic platforms. ...
Synthesis of Cortistatin Alkaloids and a Versatile Synthesis of Isoquinolines
(2012-08-10)
The cortistatins are a recently identified class of marine natural products that were found to exhibit potent and selective inhibition of human umbilical vein endothelial cells (HUVECs), making them promising leads for the ...