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Molecular Motors of ESX-Type Secretion Systems
(2012-12-17)
Tuberculosis is an enormous global health problem. Despite decades of research, the mechanism(s) by which Mycobacterium tuberculosis (Mtb) mediates virulence remains incompletely understood. The ESX-1 secretion system is ...
Neuronal Tuning and Its Role in Attention
(2012-12-17)
The activity of sensory neurons can be modulated by both external stimuli and an animal’s internal state. Characterizing the role of these bottom-up and top-down factors as well as the way in which they interact is critical ...
Robotic Catheters for Beating Heart Surgery
(2012-12-12)
Compliant and flexible cardiac catheters provide direct access to the inside of the heart via the vascular system without requiring clinicians to stop the heart or open the chest. However, the fast motion of the intracardiac ...
MicroRNAs in Normal and Malignant Lymphocytes
(2012-12-12)
MicroRNAs (miRNAs) are 20-22 nucleotide non-coding RNAs that can play important roles in developmental transitions by post-transcriptional regulation of mRNA translation and stability. We profiled miRNA expression in mouse ...
Mechanisms of Cross-Modal Refinement by Visual Experience
(2012-12-12)
Alteration of one sensory system can have striking effects on the processing and organization of the remaining senses, a phenomenon known as cross-modal plasticity. The goal of this thesis was to understand the circuit ...
Visual Attention and the Role of Normalization
(2012-12-12)
Visual perception can be improved by the intentional allocation of attention to specific visual components. This “top-down” attention can improve perception of specific locations in space, or of specific visual features ...
Essays in Applied Microeconomics
(2012-08-10)
Chapter 1 develops a model of parallel trading of corporate securities (shares, bonds) and derivatives in which a large trader can sometimes profitably acquire securities and the corporate control rights inherent therein ...
Exemplarity and its Limits in the Hagiographical Corpus of Thomas of Cantimpré
(2012-08-09)
This dissertation examines the hagiographical corpus of the Dominican preacher
Thomas of Cantimpré (c. 1201–1270), a critical early respondent to the burgeoning
women’s religious movement in the Southern Low Countries. ...
Exploring the nature of early social preferences: The case of music
(2012-08-06)
This dissertation aims to explore the nature of early social preferences by testing attention to a cue that might have evolved as a reliable signal of shared group membership – shared cultural knowledge. Part 1 shows that ...
Synthesis of Cortistatin Alkaloids and a Versatile Synthesis of Isoquinolines
(2012-08-10)
The cortistatins are a recently identified class of marine natural products that were found to exhibit potent and selective inhibition of human umbilical vein endothelial cells (HUVECs), making them promising leads for the ...