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dc.contributor.authorHauser, Russ B.
dc.contributor.authorAltshul, Larisa M.
dc.contributor.authorChen, Zuying
dc.contributor.authorRyan, Louise Marie
dc.contributor.authorOverstreet, James
dc.contributor.authorSchiff, Isaac
dc.contributor.authorChristiani, David C.
dc.date.accessioned2012-01-01T22:45:42Z
dc.date.issued2002
dc.identifier.citationHauser, Russ, Larisa Altshul, Zuying Chen, Louise Ryan, James Overstreet, Isaac Schiff, and David C Christiani. 2002. Environmental organochlorines and semen quality: results of a pilot study. Environmental Health Perspectives 110(3): 229-233.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:5978735
dc.description.abstractThere have been numerous studies that suggest that sperm concentrations (sperm counts) are declining in men. However, other studies suggest that sperm counts are not declining or may be increasing in some areas. Although there is disagreement on whether there is a downward temporal trend in sperm counts, the studies provide evidence that sperm counts vary by geographic location. It has been hypothesized that the geographic variation in sperm concentrations may be due to environmental exposures, lifestyle factors, or some unknown causes. To determine whether contemporary ambient levels of polychlorinated biphenyls (PCBs) and p,p'-DDE are associated with altered semen quantity and quality, we selected a study population without specific exposure to PCBs or p,p'-DDE. The present study presents the results from a pilot study on the relationship between serum PCBs and p,p'-DDE and semen quality in 29 subjects recruited from the Massachusetts General Hospital Andrology Laboratory. Of the 29 subjects, 3 had sperm concentrations < 20 million/mL, 7 had < 50% motile sperm, 9 had < 4% normal morphology, and 6 were below normal in more than one semen parameter. The 18 subjects with normal spermatozoa concentration, motility, and morphology were used as comparison subjects. The mean (SE) concentration of the sum of PCBs and p,p'-DDE was 242 ng/g lipids (34.0) and 354 ng/g lipids (120), respectively, for men with below normal motility as compared to 202 ng/g lipids (16.6) and 240 ng/g lipids (31.1), respectively, for the comparison subjects. The data showed general trends that were suggestive of an association between PCBs and p,p'-DDE and abnormal motility, as well as with sperm concentration and morphology. A full-scale study is currently in progress.en_US
dc.language.isoen_USen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.relation.isversionofdoi:10.1289/ehp.02110229en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240761/pdf/en_US
dash.licenseLAA
dc.subjectmale reproductive healthen_US
dc.subjectorganochlorinesen_US
dc.subjectpesticidesen_US
dc.subjectpolychlorinated biphenylsen_US
dc.subjectsemen qualityen_US
dc.subjectsperm concentrationen_US
dc.titleEnvironmental Organochlorines and Semen Quality: Results of a Pilot Studyen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorHauser, Russ B.
dc.date.available2012-01-01T22:45:42Z
dash.affiliation.otherHMS^Obstetrics Gynecology and Repro. Bio. - MGHen_US
dash.affiliation.otherSPH^Environmental+Occupational Medicine+Epien_US
dash.affiliation.otherSPH^Biostatisticsen_US
dash.affiliation.otherHMS^Obstetrics Gynecology and Repro. Bio. - MGHen_US
dash.affiliation.otherHMS^Medicine-Massachusetts General Hospitalen_US
dash.affiliation.otherSPH^Environmental+Occupational Medicine+Epien_US
dc.identifier.doi10.1289/ehp.02110229*
dash.contributor.affiliatedSchiff, Isaac
dash.contributor.affiliatedRyan, Louise
dash.contributor.affiliatedHauser, Russ
dash.contributor.affiliatedAltshul, Larisa
dash.contributor.affiliatedChristiani, David


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