Browsing HMS Scholarly Articles by Title
Now showing items 14831-14850 of 17928
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Rosiglitazone and Myocardial Infarction in Patients Previously Prescribed Metformin
(Public Library of Science, 2009)Objective: Rosiglitazone was found associated with approximately a 43% increase in risk of acute myocardial infarction (AMI) in a two meta-analyses of clinical trials. Our objective is to estimate the magnitude of the ... -
Rosuvastatin for primary prevention in patients with European systematic coronary risk evaluation risk ≥5% or Framingham risk >20%: post hoc analyses of the JUPITER trial requested by European health authorities
(Oxford University Press, 2010)Aims: On the basis of the JUPITER trial, European health authorities recently approved the use of rosuvastatin to reduce first major cardiovascular events among ‘high' global risk primary prevention patients defined either ... -
Rotating waves during human sleep spindles organize global patterns of activity that repeat precisely through the night
(eLife Sciences Publications, Ltd, 2016)During sleep, the thalamus generates a characteristic pattern of transient, 11-15 Hz sleep spindle oscillations, which synchronize the cortex through large-scale thalamocortical loops. Spindles have been increasingly ... -
Roughing Up Smoothened: Chemical Modulators of Hedgehog Signaling
(BioMed Central, 2002)Small-molecule antagonists of Hedgehog-pathway signaling, such as cyclopamine, have been known for some time. Now, small-molecule agonists of the Hedgehog pathway have also been identified. The finding that both antagonists ... -
Round-window delivery of neurotrophin 3 regenerates cochlear synapses after acoustic overexposure
(Nature Publishing Group, 2016)In acquired sensorineural hearing loss, such as that produced by noise or aging, there can be massive loss of the synaptic connections between cochlear sensory cells and primary sensory neurons, without loss of the sensory ... -
Roundtable Debate: Controversies in the Management of the Septic Patient – Desperately Seeking Consensus
(BioMed Central, 2005)Despite continuous advances in technologic and pharmacologic management, the mortality rate from septic shock remains high. Care of patients with sepsis includes measures to support the circulatory system and treat the ... -
Roundup 2.0: Enabling Comparative Genomics for over 1800 Genomes
(Oxford University Press, 2012)Summary: Roundup is an online database of gene orthologs for over 1800 genomes, including 226 Eukaryota, 1447 Bacteria, 113 Archaea, and 21 Viruses. Orthologs are inferred using the Reciprocal Smallest Distance algorithm. ... -
Routine dyspnea assessment and documentation: Nurses’ experience yields wide acceptance
(BioMed Central, 2017)Background: Dyspnea (breathing discomfort) is a common and distressing symptom. Routine assessment and documentation can improve management and relieve suffering. A major barrier to routine dyspnea documentation is the ... -
Routine HIV Screening in France: Clinical Impact and Cost-Effectiveness
(Public Library of Science, 2010)Background: In France, roughly 40,000 HIV-infected persons are unaware of their HIV infection. Although previous studies have evaluated the cost-effectiveness of routine HIV screening in the United States, differences in ... -
Routine HIV Screening in Portugal: Clinical Impact and Cost-Effectiveness
(Public Library of Science, 2013)Objective: To compare the clinical outcomes and cost-effectiveness of routine HIV screening in Portugal to the current practice of targeted and on-demand screening. Design: We used Portuguese national clinical and economic ... -
Routine HIV Testing in Adolescents and Young Adults Presenting to an Outpatient Clinic in Durban, South Africa
(Public Library of Science, 2012)Objectives: Although youth (12–24 years) in Sub-Saharan Africa have a high HIV risk, many have poor access to HIV testing services and are unaware of their status. Our objective was to evaluate the proportion of adolescents ... -
Routine Multiplex Mutational Profiling of Melanomas Enables Enrollment in Genotype-Driven Therapeutic Trials
(Public Library of Science, 2012)Purpose: Knowledge of tumor mutation status is becoming increasingly important for the treatment of cancer, as mutation-specific inhibitors are being developed for clinical use that target only sub-populations of patients ... -
Rpn6p, a Proteasome Subunit from Saccharomyces cerevisiae , Is Essential for the Assembly and Activity of the 26 S Proteasome
(American Society for Biochemistry and Molecular Biology, 2003)We report the functional characterization of RPN6, an essential gene from Saccharomyces cerevisiae encoding the proteasomal subunit Rpn6p. For this purpose, conditional mutants that are able to grow on galactose but not ... -
An RS Motif within the Epstein-Barr Virus BLRF2 Tegument Protein Is Phosphorylated by SRPK2 and Is Important for Viral Replication
(Public Library of Science, 2013)Epstein-Barr virus (EBV) is a gammaherpesvirus that causes infectious mononucleosis, B cell lymphomas, and nasopharyngeal carcinoma. Many of the genes required for EBV virion morphogenesis are found in all herpesviruses, ... -
RSD/CRPS: The end of the beginning
(Ovid Technologies (Wolters Kluwer Health), 2008) -
RSK Activation of Translation Factor eIF4B Drives Abnormal Increases of Laminin γ2 and MYC Protein during Neoplastic Progression to Squamous Cell Carcinoma
(Public Library of Science, 2013)Overexpression of the basement membrane protein Laminin γ2 (Lamγ2) is a feature of many epidermal and oral dysplasias and all invasive squamous cell carcinomas (SCCs). This abnormality has potential value as an immunohistochemical ... -
The RSSearch™ Registry: patterns of care and outcomes research on patients treated with stereotactic radiosurgery and stereotactic body radiotherapy
(BioMed Central, 2013)Background: The RSSearch™ Registry is a multi-institutional, observational, ongoing registry established to standardize data collection from patients treated with stereotactic radiosurgery (SRS) and/or stereotactic body ... -
rSW-seq: Algorithm for Detection of Copy Number Alterations in Deep Sequencing Data
(BioMed Central, 2010)Background: Recent advances in sequencing technologies have enabled generation of large-scale genome sequencing data. These data can be used to characterize a variety of genomic features, including the DNA copy number ... -
rtracklayer: an R package for interfacing with genome browsers
(Oxford University Press, 2009)Summary: The rtracklayer package supports the integration of existing genome browsers with experimental data analyses performed in R. The user may (i) transfer annotation tracks to and from a genome browser and (ii) create ... -
Rule-Based Cell Systems Model of Aging using Feedback Loop Motifs Mediated by Stress Responses
(Public Library of Science, 2010)Investigating the complex systems dynamics of the aging process requires integration of a broad range of cellular processes describing damage and functional decline co-existing with adaptive and protective regulatory ...