Browsing HMS Scholarly Articles by Title
Now showing items 2168-2187 of 17922
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CATCHR and HOPS-CORVET tethering complexes share a similar architecture
(2016)We show that the Saccharomyces cerevisiae GARP complex and the Cog1-4 subcomplex of the COG complex, both members of the complexes associated with tethering containing helical rods (CATCHR) family of multisubunit tethering ... -
Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome
(Public Library of Science, 2012)Identifying patients who are potential placebo responders has major implications for clinical practice and trial design. Catechol-O-methyltransferase (COMT), an important enzyme in dopamine catabolism plays a key role in ... -
Catecholate Siderophores Protect Bacteria from Pyochelin Toxicity
(Public Library of Science, 2012)Background: Bacteria produce small molecule iron chelators, known as siderophores, to facilitate the acquisition of iron from the environment. The synthesis of more than one siderophore and the production of multiple ... -
The Categorical Representation of Facial Expressions by 7-Month-Old Infants
(American Psychological Association (APA), 1988)We investigated the ability of 7-month-olds to categorize the facial expressions happy, fear, and surprise when these expressions varied both by the model depicting the expression and by how intensely the expression was ... -
Category-specific visual responses of single neurons in the human medial temporal lobe
(Nature Publishing Group, 2000) -
categoryCompare, an analytical tool based on feature annotations
(Frontiers Media S.A., 2014)Assessment of high-throughput—omics data initially focuses on relative or raw levels of a particular feature, such as an expression value for a transcript, protein, or metabolite. At a second level, analyses of annotations ... -
Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo
(BioMed Central, 2009)Background: Elevated SNCA gene expression and intracellular accumulation of the encoded α-synuclein (aSyn) protein are associated with the development of Parkinson disease (PD). To date, few enzymes have been examined for ... -
Cathepsin K Deficiency Reduces Elastase Perfusion-Induced Abdominal Aortic Aneurysms in Mice
(Ovid Technologies (Wolters Kluwer Health), 2011)Objective: Cathepsin K (CatK) is one of the most potent mammalian elastases. We have previously shown increased expression of CatK in human abdominal aortic aneurysm (AAA) lesions. Whether this protease participates directly ... -
Cathepsin K knockout alleviates aging-induced cardiac dysfunction
(BlackWell Publishing Ltd, 2014)Aging is a major risk factor for cardiovascular disease. It has previously been shown that protein levels of cathepsin K, a lysosomal cysteine protease, are elevated in the failing heart and that genetic ablation of cathepsin ... -
Cathepsin K Knockout Mitigates High-Fat Diet–Induced Cardiac Hypertrophy and Contractile Dysfunction
(American Diabetes Association, 2013)The cysteine protease cathepsin K has been implicated in pathogenesis of cardiovascular disease. We hypothesized that ablation of cathepsin K protects against obesity-associated cardiac dysfunction. Wild-type mice fed a ... -
Cathepsin K-mediated notch1 activation contributes to neovascularization in response to hypoxia
(Nature Research (part of Springer Nature), 2014)Cysteine proteases play important roles in pathobiology. Here we reveal that cathepsin K (CatK) has a role in ischaemia-induced neovascularization. Femoral artery ligation-induced ischaemia in mice increases CatK expression ... -
Cathepsin L Activity Is Essential to Elastase Perfusion-Induced Abdominal Aortic Aneurysms in Mice
(Ovid Technologies (Wolters Kluwer Health), 2011)Objective—The development of abdominal aortic aneurysms (AAA) requires extensive aortic wall matrix degradation. Human AAA lesions express high levels of cathepsin L (CatL), one of the most potent mammalian elastases. ... -
Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells
(Elsevier BV, 2006)The cysteine protease cathepsin L is one of the most potent mammalian elastases and collagenases, widely expressed at basal levels in most tested tissues and cell types, and regulated by pro-inflammatory stimuli. The ... -
Cathepsin S Activity Controls Injury-Related Vascular Repair in Mice via the TLR2-Mediated p38MAPK and PI3K−Akt/p-HDAC6 Signaling Pathway
(Lippincott Williams & Wilkins, 2016)Objective— Cathepsin S (CatS) participates in atherogenesis through several putative mechanisms. The ability of cathepsins to modify histone tail is likely to contribute to stem cell development. Histone deacetylase 6 ... -
Cathepsin S Controls Angiogenesis and Tumor Growth via Matrix-derived Angiogenic Factors
(American Society for Biochemistry and Molecular Biology, 2006)The cysteine protease cathepsin S is highly expressed in malignant tissues. By using a mouse model of multistage murine pancreatic islet cell carcinogenesis in which cysteine cathepsin activity has been functionally ... -
Cathepsin S Signals via PAR2 and Generates a Novel Tethered Ligand Receptor Agonist
(Public Library of Science, 2014)Protease-activated receptor-2 is widely expressed in mammalian epithelial, immune and neural tissues. Cleavage of PAR2 by serine proteases leads to self-activation of the receptor by the tethered ligand SLIGRL. The ... -
Cathepsin S Supports Acid-independent Infection by Some Reoviruses
(American Society for Biochemistry and Molecular Biology, 2004) -
The causal effect of red blood cell folate on genome-wide methylation in cord blood: a Mendelian randomization approach
(BioMed Central, 2013)Background: Investigation of the biological mechanism by which folate acts to affect fetal development can inform appraisal of expected benefits and risk management. This research is ethically imperative given the ubiquity ... -
Causal inference as an emerging statistical approach in neurology: an example for epilepsy in the elderly
(Dove Medical Press, 2017)The elderly population faces an increasing number of cases of chronic neurological conditions, such as epilepsy and Alzheimer’s disease. Because the elderly with epilepsy are commonly excluded from randomized controlled ... -
Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome
(Nature Pub. Group, 2015)Polycystic ovary syndrome (PCOS) is the most common reproductive disorder in women, yet there is little consensus regarding its aetiology. Here we perform a genome-wide association study of PCOS in up to 5,184 self-reported ...