Browsing SPH Scholarly Articles by Title

Now showing items 4621-4640 of 6362

    • Polymorphisms in Serine Hydroxymethyltransferase 1 and Methylenetetrahydrofolate Reductase Interact to Increase Cardiovascular Disease Risk in Humans 

      Wernimont, Susan M.; Raiszadeh, Farbod; Stover, Patrick J.; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600; Hunter, David J.; Tang, Wenbo; Cassano, Patricia A. (Oxford University Press, 2011)
      The enzymes serine hydroxymethyltransferase 1 (gene name SHMT1) and methylenetetrahydrofolate reductase (gene name MTHFR) regulate key reactions in folate-mediated one-carbon metabolism. Common genetic variants with the ...

    • Polymorphisms in Signal Transducer and Activator of Transcription 3 and Lung Function in Asthma 

      Litonjua, Augusto Ampil; Tantisira, Kelan; Lake, Stephen; Lazarus, Ross; Richter, Brent G; Gabriel, Stacey; Silverman, Eric S; Weiss, Scott Tillman (BioMed Central, 2005)
      Background: Identifying genetic determinants for lung function is important in providing insight into the pathophysiology of asthma. Signal transducer and activator of transcription 3 is a transcription factor latent in ...

    • Polymorphisms of an Innate Immune Gene, Toll-Like Receptor 4, and Aggressive Prostate Cancer Risk: A Systematic Review and Meta-Analysis 

      Weng, Pei-Hsuan; Huang, Yi-Ling; Page, John H.; Chen, Jen-Hau; Xu, Jianfeng; Koutros, Stella; Berndt, Sonja; Chanock, Stephen; Yeager, Meredith; Witte, John S.; Eeles, Rosalind A.; Easton, Douglas F.; Neal, David E.; Donovan, Jenny; Hamdy, Freddie C.; Muir, Kenneth R.; Giles, Graham; Severi, Gianluca; Smith, Jeffrey R.; Balistreri, Carmela R.; Shui, Irene M.; Chen, Yen-Ching (Public Library of Science, 2014)
      Background: Toll-like receptor 4 (TLR4) is one of the best known TLR members expressed on the surface of several leukocytes and tissue cells and has a key function in detecting pathogen and danger-associated molecular ...

    • Polymorphisms of MUC16 (CA125) and MUC1 (CA15.3) in Relation to Ovarian Cancer Risk and Survival 

      Williams, Kristina A.; Terry, Kathryn L.; Tworoger, Shelley S.; Vitonis, Allison F.; Titus, Linda J.; Cramer, Daniel W. (Public Library of Science, 2014)
      Objective: To examine single nucleotide polymorphism (SNPs) in MUC16 (CA125) and MUC1 (CA15.3) in relation to ovarian cancer risk and survival. Methods: We genotyped germline variants of MUC16 (rs2547065, rs1559168, ...

    • Polyphenol intake and mortality risk: a re-analysis of the PREDIMED trial 

      Tresserra-Rimbau, Anna; Rimm, Eric B; Medina-Remón, Alexander; Martínez-González, Miguel A; López-Sabater, M Carmen; Covas, María I; Corella, Dolores; Salas-Salvadó, Jordi; Gómez-Gracia, Enrique; Lapetra, José; Arós, Fernando; Fiol, Miquel; Ros, Emili; Serra-Majem, Lluis; Pintó, Xavier; Muñoz, Miguel A; Gea, Alfredo; Ruiz-Gutiérrez, Valentina; Estruch, Ramón; Lamuela-Raventós, Rosa M (BioMed Central, 2014)
      Background: Polyphenols may lower the risk of cardiovascular disease (CVD) and other chronic diseases due to their antioxidant and anti-inflammatory properties, as well as their beneficial effects on blood pressure, lipids ...

    • Polyploidy can drive rapid adaptation in yeast 

      Selmecki, Anna; Maruvka, Yosef E.; Richmond, Phillip A.; Guillet, Marie; Shoresh, Noam; Sorenson, Amber; De, Subhajyoti; Kishony, Roy; Michor, Franziska; Dowell, Robin; Pellman, David (2015)
      Polyploidy is observed across the tree of life, yet its influence on evolution remains incompletely understood1–4. Polyploidy, usually whole genome duplication (WGD), is proposed to alter the rate of evolutionary adaptation. ...

    • Polysome Profiling in Liver Identifies Dynamic Regulation of Endoplasmic Reticulum Translatome by Obesity and Fasting 

      Fu, Suneng; Fan, Jason; Blanco, Joshua Aaron; Gimenez-Cassina, Alfredo; Danial, Nika; Watkins, Steve M.; Hotamisligil, Gökhan S. (Public Library of Science, 2012)
      Obesity-associated metabolic complications are generally considered to emerge from abnormalities in carbohydrate and lipid metabolism, whereas the status of protein metabolism is not well studied. Here, we performed ...

    • Pooled analyses of 13 prospective cohort studies on folate intake and colon cancer 

      Kim, Dong-Hyun; Smith-Warner, Stephanie A.; Spiegelman, Donna; Yaun, Shiaw-Shyuan; Colditz, Graham A.; Freudenheim, Jo L.; Giovannucci, Edward; Goldbohm, R. Alexandra; Graham, Saxon; Harnack, Lisa; Jacobs, Eric J.; Leitzmann, Michael; Mannisto, Satu; Miller, Anthony B.; Potter, John D.; Rohan, Thomas E.; Schatzkin, Arthur; Speizer, Frank E.; Stevens, Victoria L.; Stolzenberg-Solomon, Rachael; Terry, Paul; Toniolo, Paolo; Weijenberg, Matty P.; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600; Wolk, Alicja; Zeleniuch-Jacquotte, Anne; Hunter, David J. (Springer (part of Springer Nature), 2010)
      Studies of folate intake and colorectal cancer risk have been inconsistent. We examined the relation with colon cancer risk in a series of 13 prospective studies.Study- and sex-specific relative risks (RRs) were estimated ...

    • A Pooled Analysis of Body Mass Index and Mortality among African Americans 

      Cohen, Sarah S.; Park, Yikyung; Signorello, Lisa B.; Patel, Alpa V.; Boggs, Deborah A.; Kolonel, Laurence N.; Kitahara, Cari M.; Knutsen, Synnove F.; Gillanders, Elizabeth; Monroe, Kristine R.; de Gonzalez, Amy Berrington; Bethea, Traci N.; Black, Amanda; Fraser, Gary; Gapstur, Susan; Hartge, Patricia; Matthews, Charles E.; Park, Song-Yi; Purdue, Mark P.; Singh, Pramil; Harvey, Chinonye; Blot, William J.; Palmer, Julie R. (Public Library of Science, 2014)
      Pooled analyses among whites and East Asians have demonstrated positive associations between all-cause mortality and body mass index (BMI), but studies of African Americans have yielded less consistent results. We examined ...

    • Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk 

      Berndt, Sonja I.; Potter, John D.; Hazra, Aditi; Yeager, Meredith; Thomas, Gilles; Makar, Karen W.; Welch, Robert; Cross, Amanda J.; Huang, Wen-Yi; Schoen, Robert E.; Giovannucci, Edward; Chan, Andrew T.; Chanock, Stephen J.; Peters, Ulrike; Hunter, David J.; Hayes, Richard B. (Oxford University Press, 2008)
      Several different genetic variants at chromosome 8q24 have been related to prostate, breast and colorectal cancer risk with evidence of region-specific risk differentials for various tumor types. We investigated the ...

    • Pooled Analysis of Phosphatidylinositol 3-kinase Pathway Variants and Risk of Prostate Cancer 

      Koutros, Stella; Schumacher, Fredrick R.; Hayes, Richard B.; Ma, Jing; Huang, Wen-Yi; Albanes, Demetrius; Canzian, Federico; Chanock, Stephen J.; Crawford, E. David; Diver, W. Ryan; Feigelson, Heather Spencer; Giovanucci, Edward; Haiman, Christopher A.; Henderson, Brian E.; Hunter, David J.; Kaaks, Rudolf; Kolonel, Laurence N.; Kraft, Peter; Marchand, Loïc Le; Riboli, Elio; Siddiq, Afshan; Stampfer, Meir; Stram, Daniel O.; Thomas, Gilles; Travis, Ruth C.; Thun, Michael J.; Yeager, Meredith; Berndt, Sonja I. (American Association for Cancer Research, 2010)
      The phosphatidylinositol 3-kinase (PI3K) pathway regulates various cellular processes, including cellular proliferation and intracellular trafficking, and may affect prostate carcinogenesis. Thus, we explored the association ...

    • Pooled Results From 5 Validation Studies of Dietary Self-Report Instruments Using Recovery Biomarkers for Energy and Protein Intake 

      Freedman, Laurence; Commins, John; Moler, James; Arab, Lenore; Baer, David; Kipnis, Victor; Midthune, Douglas; Moshfegh, Alanna; Neuhouser, Marian; Prentice, Ross; Schatzkin, Arthur; Spiegelman, Donna; Subar, Amy; Tinker, Lesley; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600 (Oxford University Press, 2014)
      We pooled data from 5 large validation studies of dietary self-report instruments that used recovery biomarkers as references to clarify the measurement properties of food frequency questionnaires (FFQs) and 24-hour recalls. ...

    • Pooled Results From 5 Validation Studies of Dietary Self-Report Instruments Using Recovery Biomarkers for Potassium and Sodium Intake 

      Freedman, Laurence; Commins, John; Moler, James; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600; Tinker, Lesley; Subar, Amy; Spiegelman, Donna; Rhodes, Donna; Potischman, Nancy; Neuhouser, Marian; Moshfegh, Alanna; Kipnis, Victor; Arab, Lenore; Prentice, Ross (Oxford University Press, 2015)
      We pooled data from 5 large validation studies (1999-2009) of dietary self-report instruments that used recovery biomarkers as referents, to assess food frequency questionnaires (FFQs) and 24-hour recalls (24HRs). Here we ...

    • Pooled Testing for Effective Estimation of the Prevalence of Schistosoma mansoni 

      Mitchell, Shira Arkin; Pagano, Marcello (The American Society of Tropical Medicine and Hygiene, 2012)
      Rapid and accurate identification of the prevalence of schistosomiasis is key for control and eradication of this devastating disease. The current screening standard for intestinal schistosomiasis is the Katz-Kato method, ...

    • Poor Immune Status and Systemic Disease Are Independently Associated with Mortality in AIDS-Related Kaposi Sarcoma in Nigeria 

      Agaba, Patricia; Sule, Halima; Ojoh, Raphael; Saidu, Zakary; Mua’zu, Mohamed; Agbaji, Oche; Idoko, John; Ekong, Ernest; Murphy, Robert; Kanki, Phyllis Jean (BioMed Central, 2012)

    • Population attributable fraction of Esophageal squamous cell carcinoma due to smoking and alcohol in Uganda 

      Okello, Samson; Churchill, Cristina; Owori, Rogers; Nasasira, Benson; Tumuhimbise, Christine; Abonga, Charles Lagoro; Mutiibwa, David; Christiani, David C.; Corey, Kathleen E. (BioMed Central, 2016)
      Background: Despite the high rates and regional variation of esophageal squamous cell carcinoma (ESCC) in East Africa, the contributions of smoking and alcohol to the ESCC burden in the general population are unknown. ...

    • Population Attributable Risk of Modifiable and Nonmodifiable Breast Cancer Risk Factors in Postmenopausal Breast Cancer 

      Tamimi, Rulla; Spiegelman, Donna; Smith-Warner, Stephanie; Wang, Molin; Pazaris, Mathew; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600; Eliassen, A. Heather; Hunter, David (Oxford University Press, 2016)
      We examined the proportions of multiple types of breast cancers in the population that were attributable to established risk factors, focusing on behaviors that are modifiable at menopause. We estimated the full and partial ...

    • Population Differences in Transcript-Regulator Expression Quantitative Trait Loci 

      Bushel, Pierre R.; McGovern, Ray; Liu, Liwen; Hofmann, Oliver Marc; Huda, Ahsan; Lu, Jun; Hide, Winston; Lin, Xihong (Public Library of Science, 2012)
      Gene expression quantitative trait loci (eQTL) are useful for identifying single nucleotide polymorphisms (SNPs) associated with diseases. At times, a genetic variant may be associated with a master regulator involved in ...

    • Population effect of influenza vaccination under co-circulation of non-vaccine variants and the case for a bivalent A/H3N2 vaccine component 

      Worby, Colin J; Wallinga, Jacco; Lipsitch, Marc; Goldstein, Edward (Elsevier BV, 2017)

    • Population genomic datasets describing the post-vaccine evolutionary epidemiology of Streptococcus pneumoniae 

      Croucher, Nicholas J.; Finkelstein, Jonathan A.; Pelton, Stephen I.; Parkhill, Julian; Bentley, Stephen D.; Lipsitch, Marc; Hanage, William P. (Nature Publishing Group, 2015)
      Streptococcus pneumoniae is common nasopharyngeal commensal bacterium and important human pathogen. Vaccines against a subset of pneumococcal antigenic diversity have reduced rates of disease, without changing the frequency ...