Browsing SPH Scholarly Articles by Title
Now showing items 3951-3970 of 6362
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Modeling Dependent Gene Expression
(Institute of Mathematical Statistics, 2012)In this paper we propose a Bayesian approach for inference about dependence of high throughput gene expression. Our goals are to use prior knowledge about pathways to anchor inference about dependence among genes; to account ... -
Modeling Disease Severity in Multiple Sclerosis Using Electronic Health Records
(Public Library of Science, 2013)Objective: To optimally leverage the scalability and unique features of the electronic health records (EHR) for research that would ultimately improve patient care, we need to accurately identify patients and extract ... -
Modeling Environmental Tobacco Smoke (ETS) Infiltration in Low-Income Multifamily Housing before and after Building Energy Retrofits
(MDPI, 2016)Secondhand exposure to environmental tobacco smoke (ETS) in multifamily housing remains a health concern despite strong recommendations to implement non-smoking policies. Multiple studies have documented exposure to ETS ... -
Modeling Human Papillomavirus and Cervical Cancer in the United States for Analyses of Screening and Vaccination
(BioMed Central, 2007)Background: To provide quantitative insight into current U.S. policy choices for cervical cancer prevention, we developed a model of human papillomavirus (HPV) and cervical cancer, explicitly incorporating uncertainty about ... -
Modeling Joint Exposures and Health Outcomes for Cumulative Risk Assessment: The Case of Radon and Smoking
(MDPI AG, 2011)Community-based cumulative risk assessment requires characterization of exposures to multiple chemical and non-chemical stressors, with consideration of how the non-chemical stressors may influence risks from chemical ... -
Modeling malaria genomics reveals transmission decline and rebound in Senegal
(Proceedings of the National Academy of Sciences, 2015)To study the effects of malaria-control interventions on parasite population genomics, we examined a set of 1,007 samples of the malaria parasite Plasmodium falciparum collected in Thiès, Senegal between 2006 and 2013. The ... -
Modeling of In-Utero and Intra-Partum Transmissions to Evaluate the Efficacy of Interventions for the Prevention of Perinatal HIV
(Public Library of Science, 2015)Background: Antiretroviral treatments decrease HIV mother-to-child transmission through pre/post exposure prophylaxis and reduction of maternal viral load. We modeled in-utero and intra-partum HIV transmissions to investigate ... -
Modeling Spatial Patterns of Traffic-Related Air Pollutants in Complex Urban Terrain
(National Institute of Environmental Health Sciences, 2011)Background: The relationship between traffic emissions and mobile-source air pollutant concentrations is highly variable over space and time and therefore difficult to model accurately, especially in urban settings with ... -
Modeling the Comparative Impact of Individual Quarantine vs. Active Monitoring of Contacts for the Mitigation of COVID-19
(2020-03-08)Individual quarantine and active monitoring of contacts are core disease control strategies, particularly for emerging infectious diseases such as Coronavirus Disease 2019 (COVID-19). To estimate the comparative efficacy ... -
Modeling the Cost Effectiveness of Neuroimaging-Based Treatment of Acute Wake-Up Stroke
(Public Library of Science, 2016)Background: Thrombolytic treatment (tissue-type plasminogen activator [tPA]) is only recommended for acute ischemic stroke patients with stroke onset time <4.5 hours. tPA is not recommended when stroke onset time is unknown. ... -
Modeling the impact of the 13-valent pneumococcal conjugate vaccine serotype catch-up program using United States claims data
(BioMed Central, 2012)Background: Analysis of US claims data from April 2010 to June 2011 estimated that 39% of the 13-valent pneumococcal conjugate vaccine (PCV13) catch-up eligible cohort would ever receive the catch-up vaccination; a previous ... -
Modelling national HIV/AIDS epidemics: revised approach in the UNAIDS Estimation and Projection Package 2011
(BMJ Publishing Group, 2012)Objective: United Nations Programme on HIV/AIDS reports regularly on estimated levels and trends in HIV/AIDS epidemics, which are evaluated using an epidemiological model within the Estimation and Projection Package (EPP). ... -
Modelling seasonal variations in the age and incidence of Kawasaki disease to explore possible infectious aetiologies
(The Royal Society, 2012)The average age of infection is expected to vary during seasonal epidemics in a way that is predictable from the epidemiological features, such as the duration of infectiousness and the nature of population mixing. However, ... -
Modelling Strategic Interventions in a Population with a Total Fertility Rate of 8.3: A Cross-Sectional Study of Idjwi Island, DRC
(BioMed Central, 2012)Background: Idjwi, an island of approximately 220,000 people, is located in eastern DRC and functions semi-autonomously under the governance of two kings (mwamis). At more than 8 live births per woman, Idjwi has one of the ... -
Moderate Alcohol Consumption and Risk of Coronary Heart Disease Among Women with Type 2 Diabetes Mellitus
(American Heart Association, 2000)Background-Moderate alcohol consumption is associated with reduced risk for coronary heart disease (CI-ID) in generally healthy populations. We assessed prospectively the association between moderate alcohol intake and CHD ... -
Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors
(1999)Objective To summarise quantitatively the association between moderate alcohol intake and biological markers of risk of coronary heart disease and to predict how these changes would lower the risk.Design Meta-analysis of ... -
Moderate alcohol intake and markers of inflammation and endothelial dysfunction among diabetic men
(Springer Verlag, 2004)Aims/hypothesis. Type 2 diabetes mellitus is characterised by heightened inflammation and endothelial dysfunction. Moderate alcohol intake has been associated with a reduced risk of cardiovascular disease in Type 2 diabetic ... -
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
(BioMed Central, 2014)In comparative high-throughput sequencing assays, a fundamental task is the analysis of count data, such as read counts per gene in RNA-seq, for evidence of systematic changes across experimental conditions. Small replicate ... -
Modern mammography screening and breast cancer mortality: population study
(BMJ Publishing Group Ltd., 2014)Objective: To evaluate the effectiveness of contemporary mammography screening using individual information about screening history and breast cancer mortality from public screening programmes. Design: Prospective cohort ...