Browsing FAS Theses and Dissertations by Keyword "Malaria"
Now showing items 1-8 of 8
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An integrated chemogenomic approach exploring and exploiting prolyl-tRNA synthetase as target for next-generation malaria and cancer therapies
(2022-11-23)Malaria is an infectious disease caused by Plasmodium parasites and remains one of the world’s most pressing public health challenges with nearly half of the world’s population at risk, causing over 200 million cases and ... -
Development and Application of Lysate Microarray Technology for Quantitative Analysis of Human Disease
(2013-08-28)Reductionist biology has yielded tremendous insight into the basis of biochemistry and genetic disease. However, the remarkable failure of reductionist biology to explain complex problems, especially cancer, has led to the ... -
Ecological pressures affecting malaria transmission: sex, insecticides, and Wolbachia in Anopheles mosquitoes
(2021-09-08)Anopheles mosquitoes are the only vectors of malaria, a disease that kills over 400,000 people each year. In malaria-endemic regions, interventions aimed at the mosquito vectors through the use of insecticides have been ... -
Harnessing Evolutionary Fitness in Plasmodium falciparum for Drug Discovery and Suppressing Resistance
(2013-10-18)Malaria is a preventable and treatable disease caused by infection with Plasmodium parasites. Complex socioeconomic and political factors limit access to vector control and antimalarial drugs, and an estimated 600,000 ... -
Integrative Antiparasitic & Erythrotoxic Characterization of a Red Blood Cell Host-Biased Compound Library
(2022-05-10)Malaria is a deadly mosquito-transmitted disease caused by Apicomplexan Plasmodium parasites that infect millions of people every year: In 2020 alone, 241 million people were infected by the parasites and ~627,000 people ... -
Modeling Behavioral and Biological Complexities of Malaria Control
(2022-03-17)Malaria, caused by a single-cell parasite and transmitted by blood-feeding mosquitoes, is one of the world's leading infectious diseases in terms of both morbidity and mortality. While the first two decades of the ... -
Molecular requirements for morphogenesis in Plasmodium falciparum, the human malaria parasite
(2021-03-05)Malaria, which is caused by Plasmodium parasites, remains a major cause of illness and death worldwide. P. falciparum, the parasite responsible for severe malaria, alters its shape dramatically during development to adapt ... -
Pre-clinical studies characterizing the evolutionary dynamics of resistance to novel antimalarials in Plasmodium falciparum
(2021-05-07)Malaria, caused by protozoan parasites of the genus Plasmodium, affects millions of people and is a leading cause of childhood mortality. Antimalarial treatments save lives and are an important cornerstone of the global ...