Browsing HMS Scholarly Articles by Title

Now showing items 16840-16859 of 17922

    • Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms 

      Horikoshi, Momoko; Pasquali, Lorenzo; Wiltshire, Steven; Huyghe, Jeroen R.; Mahajan, Anubha; Asimit, Jennifer L.; Ferreira, Teresa; Locke, Adam E.; Robertson, Neil R.; Wang, Xu; Sim, Xueling; Fujita, Hayato; Hara, Kazuo; Young, Robin; Zhang, Weihua; Choi, Sungkyoung; Chen, Han; Kaur, Ismeet; Takeuchi, Fumihiko; Fontanillas, Pierre; Thuillier, Dorothée; Yengo, Loic; Below, Jennifer E.; Tam, Claudia H.T.; Wu, Ying; Abecasis, Gonçalo; Altshuler, David; Bell, Graeme I.; Blangero, John; Burtt, Noél P.; Duggirala, Ravindranath; Florez, Jose C.; Hanis, Craig L.; Seielstad, Mark; Atzmon, Gil; Chan, Juliana C.N.; Ma, Ronald C.W.; Froguel, Philippe; Wilson, James G.; Bharadwaj, Dwaipayan; Dupuis, Josee; Meigs, James B.; Cho, Yoon Shin; Park, Taesung; Kooner, Jaspal S.; Chambers, John C.; Saleheen, Danish; Kadowaki, Takashi; Tai, E. Shyong; Mohlke, Karen L.; Cox, Nancy J.; Ferrer, Jorge; Zeggini, Eleftheria; Kato, Norihiro; Teo, Yik Ying; Boehnke, Michael; McCarthy, Mark I.; Morris, Andrew P. (Oxford University Press, 2016)
      To gain insight into potential regulatory mechanisms through which the effects of variants at four established type 2 diabetes (T2D) susceptibility loci (CDKAL1, CDKN2A-B, IGF2BP2 and KCNQ1) are mediated, we undertook ...

    • Transcending differences to study the transcendent: an exploratory study of researchers’ and chaplains’ reflections on interdisciplinary spiritual care research collaboration 

      Powell, Richard A; Emanuel, Linda; Handzo, George; Lantos, John; Dunn, Laura B; Idler, Ellen L; Wilkie, Diane J; Massey, Kevin; Summerfelt, William T; Barnes, Marilyn JD; Quest, Tammie E; Kestenbaum, Allison; Steinhauser, Karen; Fitchett, George; Zollfrank, Angelika; Olsen, Annette K; Balboni, Tracy A; Sommer, Dane (BioMed Central, 2015)
      Background: Despite recognition of the centrality of professional board-certified chaplains (BCC) in palliative care, the discipline has little research to guide its practices. To help address this limitation, HealthCare ...

    • Transcranial Direct Current Stimulation Combined with Aerobic Exercise to Optimize Analgesic Responses in Fibromyalgia: A Randomized Placebo-Controlled Clinical Trial 

      Mendonca, Mariana E.; Simis, Marcel; Grecco, Luanda C.; Battistella, Linamara R.; Baptista, Abrahão F.; Fregni, Felipe (Frontiers Media S.A., 2016)
      Fibromyalgia is a chronic pain syndrome that is associated with maladaptive plasticity in neural central circuits. One of the neural circuits that are involved in pain in fibromyalgia is the primary motor cortex. We tested ...

    • Transcranial direct current stimulation modulates efficiency of reading processes 

      Thomson, Jennifer M.; Doruk, Deniz; Mascio, Bryan; Fregni, Felipe; Cerruti, Carlo (Frontiers Media S.A., 2015)
      Transcranial direct current stimulation (tDCS) is a neuromodulatory technique that offers promise as an investigative method for understanding complex cognitive operations such as reading. This study explores the ability ...

    • Transcranial Direct Current Stimulation: Challenges, Opportunities, and Impact on Psychiatry and Neurorehabilitation 

      Brunoni, Andre R.; Boggio, Paulo Sergio; Ferrucci, Roberta; Priori, Alberto; Fregni, Felipe (Frontiers Media S.A., 2013)

    • Transcranial focused ultrasound stimulation of human primary visual cortex 

      Lee, Wonhye; Kim, Hyun-Chul; Jung, Yujin; Chung, Yong An; Song, In-Uk; Lee, Jong-Hwan; Yoo, Seung-Schik (Nature Publishing Group, 2016)
      Transcranial focused ultrasound (FUS) is making progress as a new non-invasive mode of regional brain stimulation. Current evidence of FUS-mediated neurostimulation for humans has been limited to the observation of subjective ...

    • Transcranial Low-Level Laser Therapy Improves Neurological Performance in Traumatic Brain Injury in Mice: Effect of Treatment Repetition Regimen 

      Xuan, Weijun; Huang, Liyi; Wu, Qiuhe; Xuan, Yi; Ando, Takahiro; Xu, Tao; Vatansever, Fatma; Dai, Tianhong; Hamblin, Michael; Huang, Yingying (Public Library of Science, 2013)
      Low-level laser (light) therapy (LLLT) has been clinically applied around the world for a spectrum of disorders requiring healing, regeneration and prevention of tissue death. One area that is attracting growing interest ...

    • Transcranial magnetic stimulation coregistered with MRI: a comparison of a guided versus blind stimulation technique and its effect on evoked compound muscle action potentials 

      Gugino, Laverne Dennis; Rafael Romero, J; Aglio, Linda Susan; Titone, Debra; Ramirez, Marcela; Pascual-Leone, Alvaro; Grimson, Eric; Weisenfeld, Neil; Kikinis, Ron; Shenton, Martha Elizabeth (Elsevier BV, 2001)
      Introduction and methods: Compound muscle action potentials (CMAPs) elicited by transcranial magnetic stimulation (TMS) are characterized by enormous variability, even when attempts are made to stimulate the same scalp ...

    • Transcranial magnetic stimulation of the brain: guidelines for pain treatment research 

      Klein, Max M.; Treister, Roi; Raij, Tommi; Pascual-Leone, Alvaro; Park, Lawrence; Nurmikko, Turo; Lenz, Fred; Lefaucheur, Jean-Pascal; Lang, Magdalena; Hallett, Mark; Fox, Michael; Cudkowicz, Merit; Costello, Ann; Carr, Daniel B.; Ayache, Samar S.; Oaklander, Anne Louise (Wolters Kluwer, 2015)
      Abstract Recognizing that electrically stimulating the motor cortex could relieve chronic pain sparked development of noninvasive technologies. In transcranial magnetic stimulation (TMS), electromagnetic coils held against ...

    • The transcription cofactor CRTC1 protects from aberrant hepatic lipid accumulation 

      Kim, Hwijin (Nature Publishing Group, 2016)
      Nonalcoholic fatty liver disease (NAFLD) is a rapidly emerging global health-problem. NAFLD encompasses a range of conditions associated with hepatic steatosis, aberrant accumulation of fat in hepatocytes. Although obesity ...

    • The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells 

      Kurachi, Makoto; Barnitz, R. Anthony; Yosef, Nir; Odorizzi, Pamela M.; Dilorio, Michael A.; Lemieux, Madeleine E.; Yates, Kathleen; Godec, Jernej; Klatt, Martin G.; Regev, Aviv; Wherry, E. John; Haining, W. Nicholas (2014)
      The transcription factor BATF is required for interleukin 17 (IL-17)-producing helper T cell (TH17) and follicular helper T cell (TFH) differentiation. Here, we show that BATF also has a fundamental role in regulating ...

    • Transcription factor binding dynamics during human ESC differentiation 

      Tsankov, Alexander M.; Gu, Hongcang; Akopian, Veronika; Ziller, Michael J.; Donaghey, Julie; Amit, Ido; Gnirke, Andreas; Meissner, Alexander (2015)
      Summary Pluripotent stem cells provide a powerful system to dissect the underlying molecular dynamics that regulate cell fate changes during mammalian development. Here we report the integrative analysis of genome wide ...

    • The Transcription Factor Encyclopedia 

      Yusuf, Dimas; Butland, Stefanie L; Swanson, Magdalena I; Bolotin, Eugene; Ticoll, Amy; Cheung, Warren A; Cindy Zhang, Xiao Yu; Dickman, Christopher TD; Fulton, Debra L; Schnabl, Jake M; Ramos, Oscar HP; Vasseur-Cognet, Mireille; de Leeuw, Charles N; Ryffel, Gerhart U; Lam, Eric W-F; Kist, Ralf; Wilson, Miranda SC; Marco-Ferreres, Raquel; Brosens, Jan J; Beccari, Leonardo L; Bovolenta, Paola; Benayoun, Bérénice A; Monteiro, Lara J; Schwenen, Helma DC; Grontved, Lars; Wederell, Elizabeth; Mandrup, Susanne; Veitia, Reiner A; Chakravarthy, Harini; Hoodless, Pamela A; Mancarelli, M Michela; Torbett, Bruce E; Banham, Alison H; Reddy, Sekhar P; Cullum, Rebecca L; Liedtke, Michaela; Tschan, Mario P; Vaz, Michelle; Rizzino, Angie; Zannini, Mariastella; Frietze, Seth; Farnham, Peggy J; Eijkelenboom, Astrid; Brown, Philip J; Laperrière, David; Leprince, Dominique; de Cristofaro, Tiziana; Prince, Kelly L; Putker, Marrit; del Peso, Luis; Camenisch, Gieri; Wenger, Roland H; Mikula, Michal; Rozendaal, Marieke; Mader, Sylvie; Ostrowski, Jerzy; Rhodes, Simon J; Olechnowicz, Sam WZ; Breslin, Mary B; Lan, Michael S; Nanan, Kyster K; Wegner, Michael; Hou, Juan; Mullen, Rachel D; Colvin, Stephanie C; Noy, Peter John; Webb, Carol F; Witek, Matthew E; Ferrell, Scott; Daniel, Juliet M; Waldman, Scott A; Peet, Daniel J; Taggart, Michael; Jayaraman, Padma-Sheela; Karrich, Julien J; Blom, Bianca; Vesuna, Farhad; O'Geen, Henriette; Sun, Yunfu; Gronostajski, Richard M; Woodcroft, Mark W; Hough, Margaret R; Chen, Edwin; Europe-Finner, G Nicholas; Karolczak-Bayatti, Magdalena; Bailey, Jarrod; Hankinson, Oliver; Raman, Venu; LeBrun, David P; Biswal, Shyam; DeBruyne, Jason P; Hogenesch, John B; Hevner, Robert F; Héligon, Christophe; Luo, Xin M; Blank, Marissa Cathleen; Millen, Kathleen Joyce; Sharlin, David S; Forrest, Douglas; Dahlman-Wright, Karin; Zhao, Chunyan; Mishima, Yuriko; Sinha, Satrajit; Chakrabarti, Rumela; Portales-Casamar, Elodie; Sladek, Frances M; Bradley, Philip H; Wasserman, Wyeth W; Van Rechem, Capucine; Boulay, Gaylor; Simpson, Elizabeth M; Lim, Jonathan S; Park, Jason; Harvey, Christopher J (BioMed Central, 2012)
      Here we present the Transcription Factor Encyclopedia (TFe), a new web-based compendium of mini review articles on transcription factors (TFs) that is founded on the principles of open access and collaboration. Our consortium ...

    • The transcription factor ERG increases expression of neurotransmitter receptors on prostate cancer cells 

      Kissick, Haydn T.; On, Seung T.; Dunn, Laura K.; Sanda, Martin G.; Asara, John M.; Pellegrini, Kathryn L.; Noel, Jonathan K.; Arredouani, Mohamed S. (BioMed Central, 2015)
      Background: The TMPRSS2-ERG gene fusion occurs in about half of prostate cancer (PCa) cases and results in overexpression of the transcription factor ERG. Overexpression of ERG has many effects on cellular function. However, ...

    • Transcription Factor FoxO1 Is Essential for Enamel Biomineralization 

      Poché, Ross A.; Sharma, Ramaswamy; Garcia, Monica D.; Wada, Aya M.; Nolte, Mark J.; Udan, Ryan S.; Paik, Ji-Hye; DePinho, Ronald A.; Bartlett, John D.; Dickinson, Mary E. (Public Library of Science, 2012)
      The Transforming growth factor \(\beta\) (Tgf-\(\beta\)) pathway, by signaling via the activation of Smad transcription factors, induces the expression of many diverse downstream target genes thereby regulating a vast array ...

    • Transcription Factor IRF8 Directs a Silencing Programme for TH17 Cell Differentiation 

      Ouyang, Xinshou; Zhang, Ruihua; Yang, Jianjun; Li, Qingshan; Qin, Lihui; Liu, Jianguo; Ning, Huan; Shin, Min Sun; Gupta, Monica; Qi, Chen-Feng; Lira, Sergio A.; Morse, Herbert C.; Ozato, Keiko; Mayer, Lloyd; Xiong, Huabao; Zhu, Cheng; He, John Cijiang (Nature Publishing Group, 2011)
      T\(_H\)17 cells are recognized as a unique subset of T helper cells that have critical roles in the pathogenesis of autoimmunity and tissue inflammation. Although RORγt is necessary for the generation of T\(_H\)17 cells, ...

    • The Transcription Factor MIST1 Is a Novel Human Gastric Chief Cell Marker Whose Expression Is Lost in Metaplasia, Dysplasia, and Carcinoma 

      Lennerz, Jochen K.M.; Kim, Seok-Hyung; Oates, Edward L.; Huh, Won Jae; Doherty, Jason M.; Tian, Xiaolin; Bredemeyer, Andrew J.; Goldenring, James R.; Lauwers, Gregory Y.; Shin, Young-Kee; Mills, Jason C. (Elsevier BV, 2010)
      The lack of reliable molecular markers for normal differentiated epithelial cells limits understanding of human gastric carcinogenesis. Recognized precursor lesions for gastric adenocarcinoma are intestinal metaplasia and ...

    • The Transcription Factor NFATp Plays a Key Role in Susceptibility to TB in Mice 

      Via, Laura E.; Tsytsykova, Alla V.; Rajsbaum, Ricardo; Falvo, James Vincent; Goldfeld, Anne Esther (Public Library of Science, 2012)
      In T cells, the transcription factor nuclear factor of activated T cells p (NFATp) is a key regulator of the cytokine genes tumor necrosis factor (TNF) and interferon-γ (IFN-γ). Here, we show that NFATp-deficient (NFATp^(−/−)) ...

    • The transcription factor NR4A1 is essential for the development of a novel macrophage subset in the thymus 

      Tacke, Robert; Hilgendorf, Ingo; Garner, Hannah; Waterborg, Claire; Park, Kiwon; Nowyhed, Heba; Hanna, Richard N.; Wu, Runpei; Swirski, Filip K.; Geissmann, Frederic; Hedrick, Catherine C. (Nature Publishing Group, 2015)
      Tissue macrophages function to maintain homeostasis and regulate immune responses. While tissue macrophages derive from one of a small number of progenitor programs, the transcriptional requirements for site-specific ...

    • Transcription factor-pathway co-expression analysis reveals cooperation between SP1 and ESR1 on dysregulating cell cycle arrest in non-hyperdiploid multiple myeloma 

      Wang, Xujun; Yan, Zhenyu; Fulciniti, Mariateresa; Li, Yingxiang; Gkotzamanidou, Maria; Amin, Samir B; Shah, Parantu K; Zhang, Yong; Munshi, Nikhil C; Li, Cheng (2014)
      Multiple myeloma is a hematological cancer of plasma B-cells and remains incurable. Two major subtypes of myeloma, hyperdiploid (HMM) and non-hyperdiploid myeloma (NHMM), have distinct chromosomal alterations and different ...