Browsing SPH Scholarly Articles by Title

Now showing items 4206-4225 of 6362

    • A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy 

      Paez-Cortez, Jesus; Schmitt-Knosalla, Isabela; Mfarrej, Bechara; Donnarumma, Michela; Habicht, Antje; Clarkson, Michael R.; Ansari, M. Javeed; Yuan, Xueli; D'Addio, Francesca; Iacomini, John J.; Glimcher, Laurie Hollis; Sayegh, Mohamed Hassan (The Rockefeller University Press, 2008)
      T-bet plays a crucial role in Th1 development. We investigated the role of T-bet in the development of allograft rejection in an established MHC class II–mismatched (bm12 into B6) model of chronic allograft vasculopathy ...

    • Novel role of PKR in inflammasome activation and HMGB1 release 

      Lu, Ben; Nakamura, Takahisa; Inouye, Karen; Li, Jianhua; Tang, Yiting; Lundbäck, Peter; Valdes-Ferrer, Sergio I; Olofsson, Peder S.; Kalb, Thomas; Roth, Jesse; Zou, Yongrui; Erlandsson-Harris, Helena; Yang, Huan; Ting, Jenny P-Y; Wang, Haichao; Andersson, Ulf; Antoine, Daniel J.; Chavan, Sangeeta S.; Hotamisligil, Gökhan S.; Tracey, Kevin J. (2014)
      The inflammasome regulates release of caspase activation-dependent cytokines, including IL-1β, IL-18, and high-mobility group box 1 (HMGB1)1-5. During the course of studying HMGB1 release mechanisms, we discovered an ...

    • Novel structural co-expression analysis linking the NPM1-associated ribosomal biogenesis network to chronic myelogenous leukemia 

      Chan, Lawrence WC; Lin, Xihong; Yung, Godwin; Lui, Thomas; Chiu, Ya Ming; Wang, Fengfeng; Tsui, Nancy BY; Cho, William CS; Yip, SP; Siu, Parco M.; Wong, SC Cesar; Yung, Benjamin YM (Nature Publishing Group, 2015)
      Co-expression analysis reveals useful dysregulation patterns of gene cooperativeness for understanding cancer biology and identifying new targets for treatment. We developed a structural strategy to identify co-expressed ...

    • Novel targeted therapies for eosinophilic disorders 

      Wechsler, Michael E.; Fulkerson, Patricia C.; Bochner, Bruce S.; Gauvreau, Gail M.; Gleich, Gerald J.; Henkel, Tim; Kolbeck, Roland; Mathur, Sameer K.; Ortega, Hector; Patel, Jatin; Prussin, Calman; Renzi, Paolo; Rothenberg, Marc E.; Roufosse, Florence; Simon, Dagmar; Simon, Hans-Uwe; Wardlaw, Andrew; Weller, Peter Fahey; Klion, Amy D. (Elsevier BV, 2012)
      Hypereosinophilic syndromes (HESs) are a diverse group of conditions characterized by clinical manifestations attributable to eosinophilia and eosinophilic infiltration of tissues. HESs are chronic disorders with significant ...

    • De novo cis-regulatory module elicitation for eukaryotic genomes 

      Gupta, M.; Liu, Jun (Proceedings of the National Academy of Sciences, 2005)
      Transcription regulation is controlled by coordinated binding of one or more transcription factors in the promoter regions of genes. In many species, especially higher eukaryotes, transcription factor binding sites tend ...

    • NSAID analgesic ketorolac used perioperatively may suppress early breast cancer relapse: particular relevance to triple negative subgroup 

      Retsky, Michael W.; Rogers, Rick A.; Demicheli, Romano; Hrushesky, William J. M.; Gukas, Isaac; Vaidya, Jayant S.; Baum, Michael; Forget, Patrice; DeKock, Marc; Pachmann, Katharina (Springer, 2012)
      To explain a bimodal relapse hazard among early stage breast cancer patients treated by mastectomy we postulated that relapses within 4 years of surgery resulted from something that happened at about the time of surgery ...

    • Nuclear war between Israel and Iran: lethality beyond the pale 

      Dallas, Cham E; Bell, William C; Stewart, David J; Caruso, Antonio; Burkle, Frederick (Springer Nature, 2013)
      Background: The proliferation of nuclear technology in the politically volatile Middle East greatly increases the likelihood of a catastrophic nuclear war. It is widely accepted, while not openly declared, that Israel has ...

    • Nuclear War in the Middle East: Where is the Voice of Medicine and Public Health? 

      Dallas, Cham E.; Burkle, Frederick (Cambridge University Press (CUP), 2011)
      Once again, the politically volatile Middle East and accompanying rhetoric has escalated the risk of a major nuclear exchange. Diplomatic efforts have failed to make the medical consequences of such an exchange a leading ...

    • The Nucleoid Binding Protein H-NS Biases Genome-Wide Transposon Insertion Landscapes 

      Kimura, Satoshi; Hubbard, Troy P.; Davis, Brigid M.; Waldor, Matthew K. (American Society for Microbiology, 2016)
      ABSTRACT Transposon insertion sequencing (TIS; also known as TnSeq) is a potent approach commonly used to comprehensively define the genetic loci that contribute to bacterial fitness in diverse environments. A key presumption ...

    • Nursing Education and Beliefs Towards Tobacco Cessation and Control: A Cross-sectional National Survey (GHPSS) among Nursing Students in Greece 

      Patelarou, Evridiki; Vardavas, Constantine Ilias; Ntzilepi, Penelope; Warren, Charles W; Barbouni, Anastasia; Kremastinou, Jenny; Connolly, Gregrory N.; Behrakis, Panagiotis K. (BioMed Central, 2011)
      Background: Within the healthcare system, nurses have the ability to influence their patients' smoking habits through counselling. Therefore, it is of great importance to appropriately train health professionals on smoking ...

    • Nut consumption and prostate cancer risk and mortality 

      Wang, Weike; Yang, Meng; Kenfield, Stacey; Hu, Frank; Stampfer, Meir; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600; Fuchs, Charles; Giovannucci, Edward; Bao, Ying (Springer Nature, 2016)
      Background: Little is known of the association between nut consumption, and prostate cancer (PCa) incidence and survivorship. Methods: We conducted an incidence analysis and a case-only survival analysis in the Health ...

    • Nut consumption and risk of cardiovascular disease, total cancer, all-cause and cause-specific mortality: a systematic review and dose-response meta-analysis of prospective studies 

      Aune, Dagfinn; Keum, NaNa; Giovannucci, Edward; Fadnes, Lars T.; Boffetta, Paolo; Greenwood, Darren C.; Tonstad, Serena; Vatten, Lars J.; Riboli, Elio; Norat, Teresa (BioMed Central, 2016)
      Background: Although nut consumption has been associated with a reduced risk of cardiovascular disease and all-cause mortality, data on less common causes of death has not been systematically assessed. Previous reviews ...

    • Nutrient Patterns and Their Food Sources in an International Study Setting: Report from the EPIC Study 

      Moskal, Aurelie; Pisa, Pedro T.; Ferrari, Pietro; Byrnes, Graham; Freisling, Heinz; Boutron-Ruault, Marie-Christine; Cadeau, Claire; Nailler, Laura; Wendt, Andrea; Kühn, Tilman; Boeing, Heiner; Buijsse, Brian; Tjønneland, Anne; Halkjær, Jytte; Dahm, Christina C.; Chiuve, Stephanie E.; Quirós, Jose R.; Buckland, Genevieve; Molina-Montes, Esther; Amiano, Pilar; Huerta Castaño, José M.; Gurrea, Aurelio Barricarte; Khaw, Kay-Tee; Lentjes, Marleen A.; Key, Timothy J.; Romaguera, Dora; Vergnaud, Anne-Claire; Trichopoulou, Antonia; Bamia, Christina; Orfanos, Philippos; Palli, Domenico; Pala, Valeria; Tumino, Rosario; Sacerdote, Carlotta; de Magistris, Maria Santucci; Bueno-de-Mesquita, H. Bas; Ocké, Marga C.; Beulens, Joline W. J.; Ericson, Ulrika; Drake, Isabel; Nilsson, Lena M.; Winkvist, Anna; Weiderpass, Elisabete; Hjartåker, Anette; Riboli, Elio; Slimani, Nadia (Public Library of Science, 2014)
      Background: Compared to food patterns, nutrient patterns have been rarely used particularly at international level. We studied, in the context of a multi-center study with heterogeneous data, the methodological challenges ...

    • Nutrients Intake Is Associated with DNA Methylation of Candidate Inflammatory Genes in a Population of Obese Subjects 

      Bollati, Valentina; Favero, Chiara; Albetti, Benedetta; Tarantini, Letizia; Moroni, Alice; Byun, Hyang-Min; Motta, Valeria; Conti, Diana Misaela; Tirelli, Amedea Silvia; Vigna, Luisella; Bertazzi, Pier Alberto; Pesatori, Angela Cecilia (MDPI, 2014)
      The aim of the present study was to evaluate the potential association between dietary nutrients and alterations in DNA methylation in a set of five candidate genes, including CD14, Et-1, iNOS, HERV-w and TNFα, in a ...

    • Nutrition and Inflammation Serum Biomarkers Are Associated with 12-Week Mortality among Malnourished Adults Initiating Antiretroviral Therapy in Zambia 

      Blevins, Meridith; Nyirenda, Christopher; Zulu, Isaac; Mwango, Albert; Koethe, John R.; Kabagambe, Edmond K.; Shepherd, Bryan E.; Wester, C. William; Chiasera, Janelle M.; Mulenga, Lloyd B.; Heimburger, Douglas C. (BioMed Central, 2011)
      Background: A low body mass index (BMI) at antiretroviral therapy (ART) initiation is a strong predictor of mortality among HIV-infected adults in resource-constrained settings. The relationship between nutrition and ...

    • Nutritional Predictors of Acute Respiratory Infections Among Children Born to HIV-Infected Women in Tanzania 

      Mwiru, Ramadhani; Spiegelman, Donna; Hertzmark, Ellen; Duggan, Christopher; Msamanga, Gernard; Aboud, Said; Fawzi, Wafaie (Oxford University Press, 2013)
      We prospectively determined the association between undernutrition and incidence of acute respiratory infections (ARIs) among 711 children born to HIV-infected women. Overall, underweight was associated with a 58% increased ...

    • Nutritional Predictors of Insulin-like Growth Factor I and Their Relationships to Cancer in Men 

      Giovannucci, Edward; Pollak, Michael; Liu, Yan; Platz, Elizabeth A.; Majeed, Noreen; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600 (American Association for Cancer Research, 2003)
      The insulin-like growth factor (IGF) axis may play opposing roles in health and disease. The age-related declines in growth hormone and IGF-I may be associated with potentially deleterious changes in body composition and ...

    • Nutritional Status and Mortality Among HIV-Infected Patients Receiving Antiretroviral Therapy in Tanzania 

      Liu, Enju; Spiegelman, Donna; Semu, Helen; Hawkins, Claudia; Chalamilla, Guerino; Aveika, Akum; Nyamsangia, Stella; Mehta, Saurabh; Mtasiwa, Deo; Fawzi, Wafaie (Oxford University Press, 2011)
      Background. Poor nutritional status is associated with immunologic impairment and adverse health outcomes among adults infected with human immunodeficiency virus (HIV).Methods. We investigated body mass index (BMI), middle ...

    • Nutritional Status and Other Baseline Predictors of Mortality among HIV-Infected Children Initiating Antiretroviral Therapy in Tanzania 

      Mwiru, R. S.; Spiegelman, Donna Lynn; Duggan, Christopher Paul; Seage, George R.; Semu, H.; Chalamilla, G; Kisenge, R.; Fawzi, Wafaie W. (SAGE Publications, 2013)
      BACKGROUND: We assembled a prospective cohort of 3144 children less than 15 years of age initiating antiretroviral therapy (ART) in Dar es Salaam, Tanzania. METHODS: The relationships of nutritional status and other ...

    • Nutritional Status and Tuberculosis Risk in Adult and Pediatric Household Contacts 

      Aibana, Omowunmi; Acharya, Xeno; Huang, Chuan-Chin; Becerra, Mercedes C.; Galea, Jerome T.; Chiang, Silvia S.; Contreras, Carmen; Calderon, Roger; Yataco, Rosa; Velásquez, Gustavo E.; Tintaya, Karen; Jimenez, Judith; Lecca, Leonid; Murray, Megan B. (Public Library of Science, 2016)
      Background: Studies show obesity decreases risk of tuberculosis (TB) disease. There is limited evidence on whether high body mass index also protects against TB infection; how very high body mass indices influence TB risk; ...